Technology Process of 4(3H)-Quinazolinone,
7-bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-
There total 10 articles about 4(3H)-Quinazolinone,
7-bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: dichloromethane / 2.5 h / 15 - 20 °C
2: ammonium cerium (IV) nitrate / ethanol; water / 20 - 30 °C
With
ammonium cerium (IV) nitrate;
In
ethanol; dichloromethane; water;
DOI:10.3390/molecules22071086
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: iron(III) chloride; bromine; sodium hydroxide / dichloromethane; water / 1 h / 0 - 10 °C
2.1: pyridine; potassium hydroxide; potassium permanganate / water / 80 °C
3.1: ammonia; copper(I) oxide / water / 0.5 h / 30 - 40 °C
4.1: 5 h / 150 - 170 °C
5.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 115 - 125 °C
6.1: N-chloro-succinimide; hydrogenchloride / water; acetonitrile / 4 h / 20 °C
7.1: potassium tert-butylate / ethanol / 7 h / Reflux
7.2: 7 h / 0 - 50 °C
8.1: dichloromethane / 2.5 h / 15 - 20 °C
9.1: ammonium cerium (IV) nitrate / ethanol; water / 20 - 30 °C
With
pyridine; copper(I) oxide; hydrogenchloride; iron(III) chloride; potassium permanganate; N-chloro-succinimide; ammonium cerium (IV) nitrate; potassium tert-butylate; ammonia; bromine; potassium carbonate; potassium hydroxide; sodium hydroxide;
In
ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.3390/molecules22071086