6-Isoquinolinol, 1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-7-methoxy-2- methyl-

Base Information

Chemical Name:6-Isoquinolinol, 1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-7-methoxy-2- methyl-
CAS No.:64550-60-3
Molecular Formula:C₁₉H₂₃NO₄
Molecular Weight:329.396
Hs Code.:

Synonyms:

Suppliers and Price of 6-Isoquinolinol, 1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-7-methoxy-2- methyl-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-Isoquinolinol, 1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-7-methoxy-2- methyl-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
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Technology Process of 6-Isoquinolinol, 1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-7-methoxy-2- methyl-

There total 13 articles about 6-Isoquinolinol, 1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-7-methoxy-2- methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4673-02-3
6-(benzyloxy)-1-(3-(benzyloxy)-4-methoxybenzyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

: 64550-60-3
1-(3-hydroxy-4-methoxybenzyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-6-ol

Guidance literature:: With acetic acid; der Essigsaeure wurde vor dem Reaktion mit Chlorwasserstoff bei 0grad gesaettigt;

Reference yield:

: 6346-05-0
3-benzyloxy-4-methoxybenzaldehyde

: 64550-60-3
1-(3-hydroxy-4-methoxybenzyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-6-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide / methanol; N,N-dimethyl-formamide / 2 h / -10 - -9 °C / Inert atmosphere

1.2: 0.5 h / -10 °C / Inert atmosphere

2.1: sodium hydroxide; sodium tetrahydroborate; diphenyl diselenide / ethanol / 20 - 40 °C / Inert atmosphere

3.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 3 h

4.1: sodium hydroxide / chloroform; water / 16 h / 20 °C / Cooling with ice

5.1: trichlorophosphate / acetonitrile / 3 h / Inert atmosphere; Reflux

5.2: 16 h / 20 °C / Cooling with ice; Inert atmosphere

6.1: acetic acid; hydrogen; palladium on activated charcoal / methanol / 16 h / 760.05 Torr

With sodium tetrahydroborate; oxalyl dichloride; diphenyl diselenide; palladium on activated charcoal; hydrogen; acetic acid; N,N-dimethyl-formamide; potassium hydroxide; sodium hydroxide; trichlorophosphate; In methanol; ethanol; chloroform; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1002/chem.201201895

Reference yield:

: 621-59-0
isovanillin

: 64550-60-3
1-(3-hydroxy-4-methoxybenzyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-6-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / ethanol / 20 °C

2.1: potassium hydroxide / methanol; N,N-dimethyl-formamide / 2 h / -10 - -9 °C / Inert atmosphere

2.2: 0.5 h / -10 °C / Inert atmosphere

3.1: sodium hydroxide; sodium tetrahydroborate; diphenyl diselenide / ethanol / 20 - 40 °C / Inert atmosphere

4.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 3 h

5.1: sodium hydroxide / chloroform; water / 16 h / 20 °C / Cooling with ice

6.1: trichlorophosphate / acetonitrile / 3 h / Inert atmosphere; Reflux

6.2: 16 h / 20 °C / Cooling with ice; Inert atmosphere

7.1: acetic acid; hydrogen; palladium on activated charcoal / methanol / 16 h / 760.05 Torr

With sodium tetrahydroborate; oxalyl dichloride; diphenyl diselenide; palladium on activated charcoal; hydrogen; potassium carbonate; acetic acid; N,N-dimethyl-formamide; potassium hydroxide; sodium hydroxide; trichlorophosphate; In methanol; ethanol; chloroform; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1002/chem.201201895