Technology Process of 6-(benzyloxy)-1-(3-(benzyloxy)-4-methoxybenzyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
There total 13 articles about 6-(benzyloxy)-1-(3-(benzyloxy)-4-methoxybenzyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-(3-(benzyloxy)-4-methoxyphenethyl)-2-(3-(benzyloxy)-4-methoxyphenyl)-N-methylacetamide;
With
trichlorophosphate;
In
acetonitrile;
for 3h;
Inert atmosphere;
Reflux;
With
methanol; sodium tetrahydroborate;
at 20 ℃;
for 16h;
Cooling with ice;
Inert atmosphere;
DOI:10.1002/chem.201201895
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / ethanol / 20 °C
2.1: potassium hydroxide / methanol; N,N-dimethyl-formamide / 2 h / -10 - -9 °C / Inert atmosphere
2.2: 0.5 h / -10 °C / Inert atmosphere
3.1: sodium hydroxide; sodium tetrahydroborate; diphenyl diselenide / ethanol / 20 - 40 °C / Inert atmosphere
4.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 3 h
5.1: sodium hydroxide / chloroform; water / 16 h / 20 °C / Cooling with ice
6.1: trichlorophosphate / acetonitrile / 3 h / Inert atmosphere; Reflux
6.2: 16 h / 20 °C / Cooling with ice; Inert atmosphere
With
sodium tetrahydroborate; oxalyl dichloride; diphenyl diselenide; potassium carbonate; N,N-dimethyl-formamide; potassium hydroxide; sodium hydroxide; trichlorophosphate;
In
methanol; ethanol; chloroform; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1002/chem.201201895
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium hydroxide / methanol; N,N-dimethyl-formamide / 2 h / -10 - -9 °C / Inert atmosphere
1.2: 0.5 h / -10 °C / Inert atmosphere
2.1: sodium hydroxide; sodium tetrahydroborate; diphenyl diselenide / ethanol / 20 - 40 °C / Inert atmosphere
3.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 3 h
4.1: sodium hydroxide / chloroform; water / 16 h / 20 °C / Cooling with ice
5.1: trichlorophosphate / acetonitrile / 3 h / Inert atmosphere; Reflux
5.2: 16 h / 20 °C / Cooling with ice; Inert atmosphere
With
sodium tetrahydroborate; oxalyl dichloride; diphenyl diselenide; N,N-dimethyl-formamide; potassium hydroxide; sodium hydroxide; trichlorophosphate;
In
methanol; ethanol; chloroform; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1002/chem.201201895
