4-chloro-6,7-dimethoxycinnoline

Base Information

• Chemical Name: 4-chloro-6,7-dimethoxycinnoline
• CAS No.: 7357-26-8
• Molecular Formula: C10H9ClN2O2
• Molecular Weight: 224.647
• Mol file: 7357-26-8.mol

Synonyms:4-Chloro-6,7-dimethoxycinnoline

Chemical Property of 4-chloro-6,7-dimethoxycinnoline

Chemical Property:

• Vapor Pressure: 4.06E-05mmHg at 25°C
• Refractive Index: 1.604
• Boiling Point: 362.3 °C at 760 mmHg
• Flash Point: 172.9 °C
• Density: 1.321 g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-chloro-6,7-dimethoxycinnoline

There total 1 articles about 4-chloro-6,7-dimethoxycinnoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-4,5-dimethoxyacetophenone (4101-30-8) → 4-chloro-6,7-dimethoxycinnoline (7357-26-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; sodium nitrite / water / 5.17 h / -5 - 75 °C

2: trichlorophosphate; phosphorus pentachloride / 0.67 h / 70 °C

With hydrogenchloride; phosphorus pentachloride; sodium nitrite; trichlorophosphate; In water;

DOI:10.1016/j.bmcl.2014.12.054

Reference yield: 92.0%

4-chloro-6,7-dimethoxycinnoline (7357-26-8) + para-thiocresol (106-45-6) → 6,7-dimethoxy-4-p-tolylsulfanylcinnoline (21039-90-7)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at 0 - 66 ℃; for 2.16667h;

DOI:10.1016/j.tet.2004.05.059

Reference yield: 28.0%

(1-benzyl-4,5-dihydro-1H-imidazol-2-yl)acetonitrile (879014-19-4) + 4-chloro-6,7-dimethoxycinnoline (7357-26-8) → (1-benzyl-4,5-dihydro-1H-imidazol-2-yl)(6,7-dimethoxycinnolin-4-yl)acetonitrile

Guidance literature:

(1-benzyl-4,5-dihydro-1H-imidazol-2-yl)acetonitrile; 4-chloro-6,7-dimethoxycinnoline; In N,N-dimethyl-formamide; at 60 ℃; for 0.166667h;

With potassium hexamethylsilazane; In N,N-dimethyl-formamide; toluene; at 0 - 20 ℃; for 14.0833h;

upstream raw materials:

2-amino-4,5-dimethoxyacetophenone

Downstream raw materials:

(6,7-dimethoxy-cinnolin-4-yl)-(3-methoxy-phenyl)-acetonitrile

(6,7-dimethoxy-cinnolin-4-yl)-(3,4-dimethoxy-phenyl)-acetonitrile

6,7-dimethoxy-4-p-tolylsulfanylcinnoline

4-(6,7-dimethoxy-cinnolin-4-ylmethyl)-aniline

Refernces