Benzamide,4-[(1E)-3-[[2-[[2,4-dichloro-3- [[(2-methyl-8-quinolinyl)oxy]methyl]phenyl]- methylamino]-2-oxoethyl]amino]-3-oxo-1- propenyl]-N-methyl-

Base Information

Chemical Name:Benzamide,4-[(1E)-3-[[2-[[2,4-dichloro-3- [[(2-methyl-8-quinolinyl)oxy]methyl]phenyl]- methylamino]-2-oxoethyl]amino]-3-oxo-1- propenyl]-N-methyl-
CAS No.:209919-52-8
Molecular Formula:C₃₁H₂₈Cl₂N₄O₄
Molecular Weight:591.494
Hs Code.:

Benzamide,4-[(1E)-3-[[2-[[2,4-dichloro-3- [[(2-methyl-8-quinolinyl)oxy]methyl]phenyl]- methylamino]-2-oxoethyl]amino]-3-oxo-1- propenyl]-N-methyl-

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Chemical Property of Benzamide,4-[(1E)-3-[[2-[[2,4-dichloro-3- [[(2-methyl-8-quinolinyl)oxy]methyl]phenyl]- methylamino]-2-oxoethyl]amino]-3-oxo-1- propenyl]-N-methyl-

Chemical Property:

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MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Benzamide,4-[(1E)-3-[[2-[[2,4-dichloro-3- [[(2-methyl-8-quinolinyl)oxy]methyl]phenyl]- methylamino]-2-oxoethyl]amino]-3-oxo-1- propenyl]-N-methyl-

There total 10 articles about Benzamide,4-[(1E)-3-[[2-[[2,4-dichloro-3- [[(2-methyl-8-quinolinyl)oxy]methyl]phenyl]- methylamino]-2-oxoethyl]amino]-3-oxo-1- propenyl]-N-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 160647-01-8
2,6-Dichloro-3-nitrobenzyl alcohol

: 209919-52-8
FR 165649

Guidance literature:: Multi-step reaction with 9 steps

1: 81.5 percent / imidazole / dimethylformamide / 3 h / Ambient temperature

2: FeCl₃*6H₂O, C, NH₂-NH₂*H₂O / methanol; H₂O / 5 h / 70 °C

3: 89.3 percent / Et₃N / CH₂Cl₂ / 1.5 h / 0 - 20 °C

4: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 2 h

5: 92.6 percent / NH₂-NH₂*H₂O / ethanol / 1 h / Heating

6: WSCD*HCl, HOBt / dimethylformamide / 2 h / Ambient temperature

7: 81 percent / TBAF / tetrahydrofuran / 1 h / Ambient temperature

8: 69.3 percent / PPh₃, CBr₄ / CH₂Cl₂ / 3 h / Ambient temperature

9: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 2 h

With 1H-imidazole; carbon tetrabromide; WSCD*HCl; tetrabutyl ammonium fluoride; iron(III) chloride; sodium hydride; benzotriazol-1-ol; hydrazine hydrate; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm980300f

Reference yield:

: 167837-45-8
3-amino-1-(tert-butyldiphenylsilyloxymethyl)-2,6-dichlorobenzene

: 209919-52-8
FR 165649

Guidance literature:: Multi-step reaction with 7 steps

1: 89.3 percent / Et₃N / CH₂Cl₂ / 1.5 h / 0 - 20 °C

2: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 2 h

3: 92.6 percent / NH₂-NH₂*H₂O / ethanol / 1 h / Heating

4: WSCD*HCl, HOBt / dimethylformamide / 2 h / Ambient temperature

5: 81 percent / TBAF / tetrahydrofuran / 1 h / Ambient temperature

6: 69.3 percent / PPh₃, CBr₄ / CH₂Cl₂ / 3 h / Ambient temperature

7: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 2 h

With carbon tetrabromide; WSCD*HCl; tetrabutyl ammonium fluoride; sodium hydride; benzotriazol-1-ol; hydrazine hydrate; triethylamine; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980300f

Reference yield:

: 167837-44-7
tert-butyl(2,6-dichloro-3-nitrobenzyloxy)diphenylsilane

: 209919-52-8
FR 165649

Guidance literature:: Multi-step reaction with 8 steps

1: FeCl₃*6H₂O, C, NH₂-NH₂*H₂O / methanol; H₂O / 5 h / 70 °C

2: 89.3 percent / Et₃N / CH₂Cl₂ / 1.5 h / 0 - 20 °C

3: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 2 h

4: 92.6 percent / NH₂-NH₂*H₂O / ethanol / 1 h / Heating

5: WSCD*HCl, HOBt / dimethylformamide / 2 h / Ambient temperature

6: 81 percent / TBAF / tetrahydrofuran / 1 h / Ambient temperature

7: 69.3 percent / PPh₃, CBr₄ / CH₂Cl₂ / 3 h / Ambient temperature

8: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 2 h

With carbon tetrabromide; WSCD*HCl; tetrabutyl ammonium fluoride; iron(III) chloride; sodium hydride; benzotriazol-1-ol; hydrazine hydrate; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm980300f