3-(Tert-butyldiphenylsilyloxymethyl)-2,4-dichloroaniline

Base Information

Chemical Name:3-(Tert-butyldiphenylsilyloxymethyl)-2,4-dichloroaniline
CAS No.:167837-45-8
Molecular Formula:C23H25Cl2NOSi
Molecular Weight:430.449
Hs Code.:
DSSTox Substance ID:DTXSID70442296
Wikidata:Q82259499

Synonyms:167837-45-8;AGN-PC-0N7AEM;SCHEMBL6641986;3-(tert-butyldiphenylsilyloxymethyl)-2,4-dichloroaniline;DTXSID70442296;VEAVYCWCTZXUCL-UHFFFAOYSA-N;3-amino-1-(tert-butyldiphenylsilyloxy-methyl)-2,6-dichlorobenzene;3-amino-1-(tert-butyldiphenylsilyloxymethyl)-2,6-dichlorobenzene;3-amino-1-(tert-butyldiphenylsilyoxymethyl)-2,6-dichlorobenzene

Suppliers and Price of 3-(Tert-butyldiphenylsilyloxymethyl)-2,4-dichloroaniline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 0 raw suppliers

Chemical Property of 3-(Tert-butyldiphenylsilyloxymethyl)-2,4-dichloroaniline

Chemical Property:

PSA：35.25000
LogP:6.23340
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:429.1082463
Heavy Atom Count:28
Complexity:468

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)[Si](C1=CC=CC=C1)(C2=CC=CC=C2)OCC3=C(C=CC(=C3Cl)N)Cl

Technology Process of 3-(Tert-butyldiphenylsilyloxymethyl)-2,4-dichloroaniline

There total 5 articles about 3-(Tert-butyldiphenylsilyloxymethyl)-2,4-dichloroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 167837-44-7
tert-butyl(2,6-dichloro-3-nitrobenzyloxy)diphenylsilane

: 167837-45-8
3-amino-1-(tert-butyldiphenylsilyloxymethyl)-2,6-dichlorobenzene

Guidance literature:: With iron(III) chloride hexahydrate; hydrazine; In methanol; water; for 2h; Reflux;
DOI:10.1016/j.ejmech.2020.112948

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 167837-45-8
3-amino-1-(tert-butyldiphenylsilyloxymethyl)-2,6-dichlorobenzene

Guidance literature:: Multi-step reaction with 2 steps

1: 81.5 percent / imidazole / dimethylformamide / 3 h / Ambient temperature

2: FeCl₃*6H₂O, C, NH₂-NH₂*H₂O / methanol; H₂O / 5 h / 70 °C

With 1H-imidazole; iron(III) chloride; hydrazine hydrate; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm980300f

Reference yield:

: 55775-97-8
2,6-dichloro-3-nitrobenzoic acid

: 167837-45-8
3-amino-1-(tert-butyldiphenylsilyloxymethyl)-2,6-dichlorobenzene

Guidance literature:: Multi-step reaction with 3 steps

1: dimethyl sulfide borane / tetrahydrofuran / 0.5 h / Inert atmosphere; Reflux

2: 1H-imidazole; dmap / N,N-dimethyl-formamide / 25 °C

3: iron(III) chloride hexahydrate; hydrazine / methanol; water / 2 h / Reflux

With 1H-imidazole; dmap; iron(III) chloride hexahydrate; dimethyl sulfide borane; hydrazine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2020.112948