Uridine, 4-O-(2,6-dimethylphenyl)-2'-O-2-propenyl-2-thio-

Base Information

Chemical Name:Uridine, 4-O-(2,6-dimethylphenyl)-2'-O-2-propenyl-2-thio-
CAS No.:647839-06-3
Molecular Formula:C20H24N2O5S
Molecular Weight:404.487
Hs Code.:

Synonyms:

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Chemical Property of Uridine, 4-O-(2,6-dimethylphenyl)-2'-O-2-propenyl-2-thio-

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of Uridine, 4-O-(2,6-dimethylphenyl)-2'-O-2-propenyl-2-thio-

There total 5 articles about Uridine, 4-O-(2,6-dimethylphenyl)-2'-O-2-propenyl-2-thio- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 647839-05-2
2'-O-allyl-4-O-(2,6-dimethylphenyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-thiouridine

: 647839-06-3
2'-O-allyl-4-O-(2,6-dimethylphenyl)-2-thiouridine

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 20 ℃; for 0.166667h;
DOI:10.1021/jo035246b

Reference yield:

: 576-26-1,25134-01-4
2.6-dimethylphenol

: 647839-06-3
2'-O-allyl-4-O-(2,6-dimethylphenyl)-2-thiouridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: aq. Na₂CO₃; tetrabutylammonium bromide; 2,4,6-triisopropylbenzenesulfonyl chloride / CH₂Cl₂ / 15 h / 20 °C

1.2: 92 percent / Et₃N; 1,4-diazabicyclo[2,2,2]octane / acetonitrile / 0.5 h / 20 °C

2.1: 97 percent / Ph₃P; tris(dibenzylideneacetone)-dipalladium⁽⁰⁾ / tetrahydrofuran / 0.5 h / Heating

3.1: 77 percent / Lawesson's reagent / toluene / 1 h / Heating

4.1: 100 percent / tetrabutylammonium fluoride; acetic acid / tetrahydrofuran / 0.17 h / 20 °C

With Lawessons reagent; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,4,6-triisopropylphenylsulfonyl chloride; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; sodium carbonate; acetic acid; triphenylphosphine; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jo035246b

Reference yield:

: 69304-38-7
3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

: 647839-06-3
2'-O-allyl-4-O-(2,6-dimethylphenyl)-2-thiouridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: aq. Na₂CO₃; tetrabutylammonium bromide; 2,4,6-triisopropylbenzenesulfonyl chloride / CH₂Cl₂ / 15 h / 20 °C

1.2: 92 percent / Et₃N; 1,4-diazabicyclo[2,2,2]octane / acetonitrile / 0.5 h / 20 °C

2.1: 97 percent / Ph₃P; tris(dibenzylideneacetone)-dipalladium⁽⁰⁾ / tetrahydrofuran / 0.5 h / Heating

3.1: 77 percent / Lawesson's reagent / toluene / 1 h / Heating

4.1: 100 percent / tetrabutylammonium fluoride; acetic acid / tetrahydrofuran / 0.17 h / 20 °C

With Lawessons reagent; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,4,6-triisopropylphenylsulfonyl chloride; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; sodium carbonate; acetic acid; triphenylphosphine; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jo035246b