4-O-(2,6-dimethylphenyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

Base Information

Chemical Name:4-O-(2,6-dimethylphenyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine
CAS No.:459172-82-8
Molecular Formula:C₂₉H₄₆N₂O₇Si₂
Molecular Weight:590.864
Hs Code.:

Synonyms:4-O-(2,6-dimethylphenyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-O-(2,6-dimethylphenyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

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Technology Process of 4-O-(2,6-dimethylphenyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

There total 1 articles about 4-O-(2,6-dimethylphenyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 576-26-1,25134-01-4
2.6-dimethylphenol

: 69304-38-7
3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

: 459172-82-8
4-O-(2,6-dimethylphenyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

Guidance literature:: 3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine; With 2,4,6-triisopropylphenylsulfonyl chloride; tetrabutylammomium bromide; sodium carbonate; In dichloromethane; at 20 ℃; for 15h;

2.6-dimethylphenol; With 1,4-diaza-bicyclo[2.2.2]octane; triethylamine; In acetonitrile; at 20 ℃; for 0.5h;
DOI:10.1021/jo035246b

Reference yield: 97.0%

: 1469-70-1
allyl ethyl carbonate

: 459172-82-8
4-O-(2,6-dimethylphenyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

: 647839-04-1
2'-O-allyl-4-O-(2,6-dimethylphenyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine; In tetrahydrofuran; for 0.5h; Heating;
DOI:10.1021/jo035246b

Reference yield:

: 459172-82-8
4-O-(2,6-dimethylphenyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

: 2'-O-methyl-4-O-(2,6-dimethylphenyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-thiouridine

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / NaH / dimethylformamide / 0.17 h / 20 °C

2: 77 percent / phosphorus pentasulfide; K₂CO₃ / toluene / 3 h / Heating

With diphosphorus pentasulfide; sodium hydride; potassium carbonate; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo035246b