2-(3-CHLOROPHENYL)ACETOPHENONE

Base Information

• Chemical Name: 2-(3-CHLOROPHENYL)ACETOPHENONE
• CAS No.: 27798-43-2
• Molecular Formula: C14H11 Cl O
• Molecular Weight: 230.694
• Hs Code.: 2914700090
• Mol file: 27798-43-2.mol

Synonyms:Acetophenone,2-(m-chlorophenyl)- (6CI,7CI,8CI); 2-(3-Chlorophenyl)-1-phenylethanone;3-Chlorobenzyl phenyl ketone; NSC 59912

Chemical Property of 2-(3-CHLOROPHENYL)ACETOPHENONE

Chemical Property:

• Vapor Pressure: 4.34E-05mmHg at 25°C
• Melting Point: 43 °C
• Boiling Point: 350.6°Cat760mmHg
• Flash Point: 192.2°C
• PSA: 17.07000
• Density: 1.191g/cm³
• LogP: 3.76540

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(3-CHLOROPHENYL)ACETOPHENONE ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3-CHLOROPHENYL)ACETOPHENONE

There total 16 articles about 2-(3-CHLOROPHENYL)ACETOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-(3-chlorophenyl)-2-oxo-2-phenylethyl benzoate → 2-(3-chlorophenyl)-1-phenylethanone (27798-43-2)

Guidance literature:

With palladium(II) trifluoroacetate; hydrogen; [(4S)-4-[5-bis(3,5-di-tert-butyl-4-methoxyphenyl)phosphanyl-1,3-benzodioxol-4-yl]-4,5,6,7-tetrahydro-1,3-benzodioxol-5-yl]-bis(3,5-di-tert-butyl-4-methoxyphenyl)phosphane; In acetone; at 35 ℃; for 24h; under 22502.3 Torr; chemoselective reaction; Glovebox; Autoclave;

DOI:10.1002/anie.201603590

Reference yield: 93.0%

benzoic acid methyl ester (93-58-3,5705-52-2,80226-58-0) + 3-chlorophenylacetic acid (1878-65-5) → 2-(3-chlorophenyl)-1-phenylethanone (27798-43-2)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; at -4 ℃; Inert atmosphere;

DOI:10.1021/acs.jmedchem.1c00235

Reference yield: 80.0%

1-chloro-3-methylbenzene (108-41-8) + Benzoylformic acid (611-73-4) → 2-(3-chlorophenyl)-1-phenylethanone (27798-43-2)

Guidance literature:

With tris(triphenylphosphine)ruthenium(II) chloride; di-tert-butyl peroxide; at 120 ℃; for 12h; Sealed tube; Inert atmosphere;

DOI:10.1002/ejoc.202100432

upstream raw materials:

α-(3-Chlorophenoxy)acetophenone

benzene

m-Chlorobenzaldehyde

3-chlorophenylacetic acid

Downstream raw materials:

α-Brom-α-(3-chlor-phenyl)-acetophenon

4'-chlorobenzoin

2-(3-Chloro-phenyl)-2-methyl-1-phenyl-propan-1-one

2-(3-chloro-phenyl)-1-phenyl-ethylamine