4-Hydroxyalprazolam

Base Information

Chemical Name:4-Hydroxyalprazolam
CAS No.:30896-57-2
Deprecated CAS:144147-12-6
Molecular Formula:C17H13 Cl N4 O
Molecular Weight:324.769
Hs Code.:2933990090
UNII:U0COM4319X
DSSTox Substance ID:DTXSID90932240
Nikkaji Number:J807.558A
Wikidata:Q27290520
ChEMBL ID:CHEMBL1313
Mol file:30896-57-2.mol

Synonyms:4-hydroxyalprazolam

Suppliers and Price of 4-Hydroxyalprazolam

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemtos
4-Hydroxy-Alprazolam-d5
5 mg
$ 2000.00

Chemtos
4-Hydroxy-Alprazolam
10 mg
$ 1500.00

Cayman Chemical
4-Hydroxyalprazolam ≥95%
5mg
$ 70.00

Cayman Chemical
4-Hydroxyalprazolam ≥95%
1mg
$ 35.00

American Custom Chemicals Corporation
4-HYDROXY ALPRAZOLAM METHANOATE 95.00%
50MG
$ 2194.50

American Custom Chemicals Corporation
4-HYDROXY ALPRAZOLAM METHANOATE 95.00%
5MG
$ 816.75

AK Scientific
4-Hydroxyalprazolam
5mg
$ 194.00

Total 11 raw suppliers

Chemical Property of 4-Hydroxyalprazolam

Chemical Property:

Vapor Pressure:2.42E-13mmHg at 25°C
Melting Point:160-162oC
Boiling Point:559.2°Cat760mmHg
PKA:11.59±0.40(Predicted)
Flash Point:292°C
PSA：63.30000
Density:1.45g/cm³
LogP:2.50660
Storage Temp.:Controlled Substance, -20?C Freezer
XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:324.0777887
Heavy Atom Count:23
Complexity:468

Purity/Quality:

99% ^*data from raw suppliers

4-Hydroxy-Alprazolam-d5 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NN=C2N1C3=C(C=C(C=C3)Cl)C(=NC2O)C4=CC=CC=C4
Description Alprazolam is a benzodiazepine with anxiolytic and sedative actions. 4-Hydroxyalprazolam is a major metabolite of alprazolam, produced by the actions of cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5. It may be detected in serum or, in a glucuronidated form, in urine. Alternatively, 4-hydroxyalprazolam can be further metabolized to benzophenone.
Uses A metabolite of Alprazolam, a benzodiazepine. Controlled Substance

Technology Process of 4-Hydroxyalprazolam

There total 7 articles about 4-Hydroxyalprazolam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.7%

: 30896-67-4
8-chloro-4-hydroxy-1-methyl-6-phenyl-4H-s-triazolo<4,3-a><1,4>benzodiazepine acetate

: 30896-57-2,144147-12-6
4-Hydroxyalprazolam

Guidance literature:: With sodium hydroxide; In ethanol; for 1h;
DOI:10.1021/jm00180a012

Reference yield: 51.0%

: 36916-20-8
4-(2-benzoyl-4-chlorophenyl)-5-methyl-4H-1,2,4-triazole-3-carboxaldehyde

: 30896-57-2,144147-12-6
4-Hydroxyalprazolam

Guidance literature:: With ammonia; In ethanol; for 5h; Ambient temperature;
DOI:10.1021/jm00180a012

Reference yield:

: 36916-14-0
10-chloro-6-methyl-11b-phenyl-3H,11bH-oxazirino<3,2-d>-s-triazolo<4,3-a><1,4>benzodiazepine

: 30896-57-2,144147-12-6
4-Hydroxyalprazolam

Guidance literature:: Multi-step reaction with 3 steps

1: 15.7 percent / 1,3,5-trimethyl-benzene / 0.25 h / Heating

2: 36 percent / AcOH / 0.5 h / Heating

3: 84.7 percent / 1N NaOH / aq. ethanol / 1 h

With sodium hydroxide; acetic acid; In ethanol; 1,3,5-trimethyl-benzene;
DOI:10.1021/jm00180a012