36916-20-8

Usage

Chemical Properties

Off-white solid

Uses

Intermediate in the preparation of Alprazolam impurities.

Upstream product

• 27537-93-5 6-chloro-2-hydrazino-4-phenylquinoline 
• 10352-30-4 2,6-dichloro-4-phenylquinoline 
• 28981-97-7 alprazolam 
• 36916-14-0 10-chloro-6-methyl-11b-phenyl-3H,11bH-oxazirino<3,2-d>-s-triazolo<4,3-a><1,4>benzodiazepine 
• 36916-18-4 7-Chloro-1-methyl-5-phenyl-s-triazolo<4,3-a>quinoline 

Downstream Products

• 36916-15-1 8-chloro-5,6-dihydro-1-methyl-6-phenyl-4H-s-triazolo<4,3-a><1,4>benzodiazepin-4-one 
• 36916-19-5 5-chloro-2-(3-methyl-4H-1,2,4-triazol-4-yl)benzophenone 
• 30896-57-2 4-Hydroxyalprazolam 

Relevant academic research and scientific papers

8-Chloro-1-methyl-6-phenyl-4H-s-triazolobenzodiazepines with Substituents at C-4

A series of 8-chloro-1-methyl-6-phenyl-4H-s-triazolobenzodiazepines with substituents at C-4 was prepared and evaluated for antianxiety potential.It was found that substitution at this position generally decreased the activity in this series.

Novel synthesis of the pharmacologically important 1-substituted-6-phenyl-4H-s-triazolo[4,3-α][1,4]benzodiazepines

Several 6-phenyl-4H-s-triazolo[4,3-α][1,4]benzodiazepines have useful biological activity both in experimental animals and in man. This manuscript describes a novel synthesis of these compounds from intermediates that do not have a pre-formed benzodiazepine ring system.