Pyrimidine, 5-[4-[[(4-methylphenyl)methyl]thio]-1,2,5-thiadiazol-3-yl]-

Base Information

Chemical Name:Pyrimidine, 5-[4-[[(4-methylphenyl)methyl]thio]-1,2,5-thiadiazol-3-yl]-
CAS No.:647860-10-4
Molecular Formula:C14H12N4S2
Molecular Weight:300.408
Hs Code.:

Synonyms:

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Chemical Property of Pyrimidine, 5-[4-[[(4-methylphenyl)methyl]thio]-1,2,5-thiadiazol-3-yl]-

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of Pyrimidine, 5-[4-[[(4-methylphenyl)methyl]thio]-1,2,5-thiadiazol-3-yl]-

There total 4 articles about Pyrimidine, 5-[4-[[(4-methylphenyl)methyl]thio]-1,2,5-thiadiazol-3-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 287472-26-8
5-(4-chloro-[1,2,5]thiadiazol-3-yl)pyrimidine

: 647860-10-4
5-[4-(4-methyl-benzylsulfanyl)-[1,2,5]thiadiazol-3-yl]-pyrimidine

Guidance literature:: 5-(4-chloro-[1,2,5]thiadiazol-3-yl)pyrimidine; With sodium hydrogensulfide; In N,N-dimethyl-formamide; at 100 ℃; for 24h;

4-methylbenzyl halide; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1002/ardp.200300730

Reference yield:

: 10070-92-5
pyrimidine-5-carbaldehyde

: 647860-10-4
5-[4-(4-methyl-benzylsulfanyl)-[1,2,5]thiadiazol-3-yl]-pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: H₂O / 5 - 10 °C

1.2: 67 percent / acetic acid / H₂O / 2 h / 20 °C

2.1: 39 percent / NH₄Cl; NH₄OH / acetonitrile / 3 h / Heating

3.1: 73 percent / S₂Cl₂ / dimethylformamide / 2 h / 80 °C

4.1: sodium hydrosulfide hydrate / dimethylformamide / 24 h / 100 °C

4.2: 72 percent / K₂CO₃ / dimethylformamide / 20 °C

With disulfur dichloride; ammonium hydroxide; sodium hydrogensulfide; ammonium chloride; In water; N,N-dimethyl-formamide; acetonitrile; 2.1: Strecker reaction;
DOI:10.1002/ardp.200300730

Reference yield:

: 287472-25-7
amino(pyrimidin-5-yl)acetonitrile

: 647860-10-4
5-[4-(4-methyl-benzylsulfanyl)-[1,2,5]thiadiazol-3-yl]-pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 73 percent / S₂Cl₂ / dimethylformamide / 2 h / 80 °C

2.1: sodium hydrosulfide hydrate / dimethylformamide / 24 h / 100 °C

2.2: 72 percent / K₂CO₃ / dimethylformamide / 20 °C

With disulfur dichloride; sodium hydrogensulfide; In N,N-dimethyl-formamide;
DOI:10.1002/ardp.200300730