2-Amino-2-(pyrimidin-5-yl)acetonitrile

Base Information

Chemical Name:2-Amino-2-(pyrimidin-5-yl)acetonitrile
CAS No.:287472-25-7
Molecular Formula:C₆H₆N₄
Molecular Weight:134.14
Hs Code.:
DSSTox Substance ID:DTXSID701301260
Mol file:287472-25-7.mol

Synonyms:287472-25-7;2-amino-2-(pyrimidin-5-yl)acetonitrile;SCHEMBL8305141;Amino(pyrimidin-5-yl)acetonitrile;YGRHTKCWNUWRLG-UHFFFAOYSA-N;DTXSID701301260;Amino (pyrimidin-5-yl)acetonitrile;I+/--Amino-5-pyrimidineacetonitrile;AKOS006337620;5-Pyrimidineacetonitrile, alpha-amino- (9CI)

Suppliers and Price of 2-Amino-2-(pyrimidin-5-yl)acetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of 2-Amino-2-(pyrimidin-5-yl)acetonitrile

Chemical Property:

PSA：75.59000
LogP:0.70028
XLogP3:-1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:134.059246208
Heavy Atom Count:10
Complexity:141

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C=NC=N1)C(C#N)N

Technology Process of 2-Amino-2-(pyrimidin-5-yl)acetonitrile

There total 2 articles about 2-Amino-2-(pyrimidin-5-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 287472-24-6
hydroxy(pyrimidin-5-yl)acetonitrile

: 287472-25-7
amino(pyrimidin-5-yl)acetonitrile

Guidance literature:: With ammonium hydroxide; ammonium chloride; In acetonitrile; for 3h; Heating;
DOI:10.1002/(SICI)1521-4184(20005)333:5<113::AID-ARDP113>3.0.CO;2-9

Reference yield:

: 10070-92-5
pyrimidine-5-carbaldehyde

: 287472-25-7
amino(pyrimidin-5-yl)acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: H₂O / 5 - 10 °C

1.2: 67 percent / acetic acid / H₂O / 2 h / 20 °C

2.1: 39 percent / NH₄Cl; NH₄OH / acetonitrile / 3 h / Heating

With ammonium hydroxide; ammonium chloride; In water; acetonitrile; 2.1: Strecker reaction;
DOI:10.1002/ardp.200300730

Reference yield:

: 287472-25-7
amino(pyrimidin-5-yl)acetonitrile

: 146422-56-2
1-Triphenylmethyl-5(3(1-n-heptanoxy)-1,2,5-thiadiazol-4-yl)-1,4,5,6-tetrahydropyrimidine HCl

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate / hydrogenchloride

2: hydrogenchloride / Pd-on-carbon / water

3: diaza-bicyclo-undecene / N,N-dimethyl-formamide

4: ammonium hydroxide / pyridine

5: NaH / chloroform; N,N-dimethyl-formamide

With hydrogenchloride; ammonium hydroxide; NaH; diaza-bicyclo-undecene; sodium carbonate; Pd-on-carbon; In pyridine; hydrogenchloride; chloroform; water; N,N-dimethyl-formamide;