tert-Butyl 3-oxo-4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-Butyl 3-oxo-4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate
CAS No.:647863-25-0
Molecular Formula:C12H16F3NO4
Molecular Weight:295.259
Hs Code.:2933399090
DSSTox Substance ID:DTXSID80594033
Mol file:647863-25-0.mol

Synonyms:647863-25-0;tert-Butyl 3-oxo-4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate;tert-Butyl 3-oxo-4-(trifluoroacetyl)piperidine-1-carboxylate;1-Boc-3-oxo-4-(2,2,2-trifluoroacetyl)piperidine;tert-Butyl 4-(2,2,2-trifluoroacetyl)-3-oxopiperidine-1-carboxylate;SCHEMBL1006353;DTXSID80594033;XAB86325;tert-Butyl3-oxo-4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate;AKOS016001702;PB11576;AS-41128;1-Boc-3-oxo-4-(trifluoroacetyl)piperidine;DB-087648;CS-0048270;A867824;1-tert-butoxycarbonyl-4-(trifluoroacetyl)-3-piperidinone;t-butyl 3-oxo-4-(trifluoroacetyl)piperidin-1-carboxylate;t-butyl 3-oxo-4-(trifluoroacetyl)-piperidin-1-carboxylate;tert-butyl-3-oxo-4-(trifluoroacetyl)-piperidine-1-carboxylate

Suppliers and Price of tert-Butyl 3-oxo-4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Synthonix
1-Boc-3-oxo-4-(2,2,2-trifluoroacetyl)piperidine 95+%
250mg
$ 290.00

Synthonix
1-Boc-3-oxo-4-(2,2,2-trifluoroacetyl)piperidine 95+%
5g
$ 2160.00

Matrix Scientific
1-Boc-3-oxo-4-(2,2,2-trifluoroacetyl)piperidine 95+%
1g
$ 1782.00

Crysdot
tert-Butyl3-oxo-4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate 95+%
1g
$ 614.00

Chemenu
tert-butyl4-(2,2,2-trifluoroacetyl)-3-oxopiperidine-1-carboxylate 95%
1g
$ 580.00

American Custom Chemicals Corporation
TERT-BUTYL-3-OXO-4-(2,2,2-TRIFLUOROACETYL)PIPERIDINE-1-CARBOXYLATE 95.00%
5MG
$ 496.84

Alichem
tert-Butyl3-oxo-4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate
250mg
$ 344.02

Alichem
tert-Butyl3-oxo-4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate
1g
$ 842.34

AK Scientific
tert-Butyl3-oxo-4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate
1g
$ 2455.00

Total 14 raw suppliers

Chemical Property of tert-Butyl 3-oxo-4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate

Chemical Property:

PSA：63.68000
LogP:1.88180
Storage Temp.:2-8°C
XLogP3:2.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:295.10314248
Heavy Atom Count:20
Complexity:425

Purity/Quality:

99%, ^*data from raw suppliers

1-Boc-3-oxo-4-(2,2,2-trifluoroacetyl)piperidine 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(C(=O)C1)C(=O)C(F)(F)F

Technology Process of tert-Butyl 3-oxo-4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate

There total 3 articles about tert-Butyl 3-oxo-4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 383-63-1
ethyl trifluoroacetate,

: 98977-36-7
3-oxo-piperidine-1-carboxylic acid tert-butyl ester

: 647863-25-0
tert-butyl 3-oxo-4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate

Guidance literature:: 3-oxo-piperidine-1-carboxylic acid tert-butyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; 1,2-dimethoxyethane; at -78 ℃; for 1h; Cooling with acetone-dry ice;

ethyl trifluoroacetate,; In tetrahydrofuran; 1,2-dimethoxyethane; at -78 - 20 ℃; for 3.5h;

Reference yield:

: 98977-36-7
3-oxo-piperidine-1-carboxylic acid tert-butyl ester

: 647863-25-0
tert-butyl 3-oxo-4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 20 ℃; for 2.33333h;

Reference yield:

: 647863-23-8
tert-butyl 5-[(trimethylsilyl)oxy]-3,4-dihydropyridine-1(2H)-carboxylate

: 647863-24-9
tert-butyl 5-[(trimethylsilyl)oxy]-3,6-dihydropyridine-1(2H)-carboxylate

: 407-25-0
trifluoroacetic anhydride

: 647863-25-0
tert-butyl 3-oxo-4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate

: 647863-26-1
tert-butyl 3-oxo-2-(trifluoroacetyl)piperidine-1-carboxylate

Guidance literature:: tert-butyl 5-[(trimethylsilyl)oxy]-3,4-dihydropyridine-1(2H)-carboxylate; tert-butyl 5-[(trimethylsilyl)oxy]-3,6-dihydropyridine-1(2H)-carboxylate; With methyllithium; In tetrahydrofuran; at -15 ℃; for 0.666667h;

trifluoroacetic anhydride; In tetrahydrofuran; at -78 ℃; for 1.5h;