(2R)-(+)-3 3-DIMETHYLGLYCIDYL

Base Information

• Chemical Name: (2R)-(+)-3 3-DIMETHYLGLYCIDYL
• CAS No.: 141700-91-6
• Molecular Formula: C12H13 N O5
• Molecular Weight: 251.239
• Mol file: 141700-91-6.mol

Synonyms:Oxiranemethanol,3,3-dimethyl-, 4-nitrobenzoate, (2R)- (9CI); Oxiranemethanol, 3,3-dimethyl-,4-nitrobenzoate, (R)-; [(2R)-3,3-Dimethyloxiran-2-yl]methyl 4-nitrobenzoate

Chemical Property of (2R)-(+)-3 3-DIMETHYLGLYCIDYL

Chemical Property:

• Vapor Pressure: 6.33E-06mmHg at 25°C
• Melting Point: 110-113oC(lit.)
• Boiling Point: 378.3°Cat760mmHg
• Flash Point: 167.2°C
• PSA: 84.65000
• Density: 1.269g/cm³
• LogP: 2.45220

Purity/Quality:

97% ^*data from raw suppliers

(2R)-(+)-3,3-DIMETHYLGLYCIDYL-4-NITROBENZOATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2R)-(+)-3 3-DIMETHYLGLYCIDYL

There total 6 articles about (2R)-(+)-3 3-DIMETHYLGLYCIDYL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

[(2R)-3,3-dimethyloxiran-2-yl]methanol (62748-09-8) + 4-nitro-benzoyl chloride (122-04-3) → [(2R)-3,3-dimethyloxiran-2-yl]methyl 4-nitrobenzoate (141700-91-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 0.166667h;

DOI:10.1021/acs.joc.9b01597

Reference yield:

(+/-)-3,3-dimethyloxirane-2-carboxaldehyde (5369-62-0) → (S)-(3,3-dimethyloxiran-2-yl)methyl 4-nitrobenzoate (106268-98-8) + [(2R)-3,3-dimethyloxiran-2-yl]methyl 4-nitrobenzoate (141700-91-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol; water / 0.5 h / 0 °C / Inert atmosphere

2: triethylamine; dmap / dichloromethane / 1.25 h / 0 - 20 °C / Inert atmosphere

With dmap; sodium tetrahydroborate; triethylamine; In methanol; dichloromethane; water;

DOI:10.1016/j.tetasy.2016.02.009

Reference yield:

(3,3-dimethyloxiranyl)methanol (18511-56-3) + 4-nitro-benzoyl chloride (122-04-3) → (S)-(3,3-dimethyloxiran-2-yl)methyl 4-nitrobenzoate (106268-98-8) + [(2R)-3,3-dimethyloxiran-2-yl]methyl 4-nitrobenzoate (141700-91-6)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 1.25h; Inert atmosphere;

DOI:10.1016/j.tetasy.2016.02.009

upstream raw materials:

(3,3-dimethyloxiranyl)methanol

4-nitro-benzoyl chloride

3-methyl-2-buten-1-ol

(+/-)-3,3-dimethyloxirane-2-carboxaldehyde