Methyl 4-aMino-5-cyanothiophene-2-carboxylate

Base Information

• Chemical Name: Methyl 4-aMino-5-cyanothiophene-2-carboxylate
• CAS No.: 648412-51-5
• Molecular Formula: C7H6N2O2S
• Molecular Weight: 182.20000
• Mol file: 648412-51-5.mol

Synonyms:methyl 4-amino-5-cyano-thiophene-2-carboxylate;2-Thiophenecarboxylic acid,4-amino-5-cyano-,methyl ester;

Chemical Property of Methyl 4-aMino-5-cyanothiophene-2-carboxylate

Chemical Property:

• PSA: 104.35000
• LogP: 1.56978

Purity/Quality:

NLT 98% ^*data from raw suppliers

Methyl4-amino-5-cyanothiophene-2-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 4-aMino-5-cyanothiophene-2-carboxylate

There total 1 articles about Methyl 4-aMino-5-cyanothiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

methyl 5-cyano-4-nitro-thiophene-2-carboxylate (648412-49-1) → methyl 4-amino-5-cyano-thiophene-2-carboxylate (648412-51-5)

Guidance literature:

methyl 5-cyano-4-nitro-thiophene-2-carboxylate; With iron; acetic acid; for 3h; Heating / reflux;

With ammonia; In water;

Reference yield: 37.0%

methyl 4-amino-5-cyano-thiophene-2-carboxylate (648412-51-5) → 3-amino-1H-thieno[3,2-c]pyrazole-5-carboxylic acid methyl ester (648411-35-2)

Guidance literature:

methyl 4-amino-5-cyano-thiophene-2-carboxylate; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 1.5h;

With hydrogenchloride; tin(ll) chloride; In water; at 5 ℃; for 3h;

With sodium hydroxide; In water; at 0 ℃; Product distribution / selectivity;

upstream raw materials:

methyl 5-cyano-4-nitro-thiophene-2-carboxylate

Downstream raw materials:

3-amino-1H-thieno[3,2-c]pyrazole-5-carboxylic acid methyl ester

Refernces

• 1、 -. "HETEROBICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS". Page 37-38. . Retrieved 2010/02/06.