Silanamine, 1,1,1-trimethyl-N-[[3-(phenylmethoxy)-2-pyridinyl]methylene]-

Base Information

Chemical Name:Silanamine, 1,1,1-trimethyl-N-[[3-(phenylmethoxy)-2-pyridinyl]methylene]-
CAS No.:648415-03-6
Molecular Formula:C₁₆H₂₀N₂OSi
Molecular Weight:284.433
Hs Code.:

Synonyms:

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Chemical Property of Silanamine, 1,1,1-trimethyl-N-[[3-(phenylmethoxy)-2-pyridinyl]methylene]-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
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MSDS Files:: SDS file from LookChem

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Technology Process of Silanamine, 1,1,1-trimethyl-N-[[3-(phenylmethoxy)-2-pyridinyl]methylene]-

There total 2 articles about Silanamine, 1,1,1-trimethyl-N-[[3-(phenylmethoxy)-2-pyridinyl]methylene]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 94454-57-6
3-(phenylmethoxy)-2-pyridinecarboxaldehyde

: 4039-32-1
lithium hexamethyldisilazane

: 648415-03-6
[1-(3-Benzyloxy-pyridin-2-yl)-meth-(E)-ylidene]-trimethylsilanyl-amine

Guidance literature:: 3-(phenylmethoxy)-2-pyridinecarboxaldehyde; lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 0.5h;

With chloro-trimethyl-silane; In tetrahydrofuran; at 0 ℃; for 0.5h;
DOI:10.1016/S0968-0896(03)00454-1

Reference yield:

: 14173-30-9
3-hydroxy-2-hydroxymethylpyridine hydrochloride

: 648415-03-6
[1-(3-Benzyloxy-pyridin-2-yl)-meth-(E)-ylidene]-trimethylsilanyl-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 66 percent / KOH / ethanol / 24 h / Heating

2.1: 73 percent / MnO₂ / CHCl₃ / 1.33 h / Heating

3.1: tetrahydrofuran / 0.5 h / 0 °C

3.2: (CH₃)3SiCl / tetrahydrofuran / 0.5 h / 0 °C

With manganese(IV) oxide; potassium hydroxide; In tetrahydrofuran; ethanol; chloroform;
DOI:10.1016/S0968-0896(03)00454-1

Reference yield:

: 648415-03-6
[1-(3-Benzyloxy-pyridin-2-yl)-meth-(E)-ylidene]-trimethylsilanyl-amine

: (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-1-hydroxy-9,10-[(1S)-2-(morpholino)ethylidenedioxy]tax-11-en-13-yl (2R,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-3-(3-hydroxy-2-pyridyl)propionate

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium diisopropylamide / tetrahydrofuran; hexane / -78 °C

1.2: tetrahydrofuran; hexane / -78 - 20 °C

2.1: 83 percent / 4-(N,N-dimethylamino)pyridine / tetrahydrofuran / 20 °C

3.1: 90 percent / LiHMDS / tetrahydrofuran / cooling

4.1: 94 percent / Bu₄NF / tetrahydrofuran / cooling

5.1: OsO₄; N-methylmorpholine N-oxide / tetrahydrofuran; H₂O; acetone / 20 °C

6.1: NaIO₄ / tetrahydrofuran; methanol; H₂O / 20 °C

7.1: NaBH₃CN; acetic acid / ethanol / 20 °C

8.1: 84 percent / H₂ / Pd(OH)2 / ethanol / ambient pressure

With dmap; sodium periodate; osmium(VIII) oxide; tetrabutyl ammonium fluoride; hydrogen; sodium cyanoborohydride; acetic acid; 4-methylmorpholine N-oxide; lithium hexamethyldisilazane; lithium diisopropyl amide; palladium dihydroxide; In tetrahydrofuran; methanol; ethanol; hexane; water; acetone;
DOI:10.1016/S0968-0896(03)00454-1