Oxazole, 2-(1-chloroethyl)-4,5-dihydro-4-(1-methylethyl)-, (4R)-

Base Information

Chemical Name:Oxazole, 2-(1-chloroethyl)-4,5-dihydro-4-(1-methylethyl)-, (4R)-
CAS No.:648428-09-5
Molecular Formula:C8H14ClNO
Molecular Weight:175.658
Hs Code.:
DSSTox Substance ID:DTXSID00460822

Synonyms:648428-09-5;Oxazole, 2-(1-chloroethyl)-4,5-dihydro-4-(1-methylethyl)-, (4R)-;DTXSID00460822

Suppliers and Price of Oxazole, 2-(1-chloroethyl)-4,5-dihydro-4-(1-methylethyl)-, (4R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Oxazole, 2-(1-chloroethyl)-4,5-dihydro-4-(1-methylethyl)-, (4R)-

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:175.0763918
Heavy Atom Count:11
Complexity:168

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)C1COC(=N1)C(C)Cl
Isomeric SMILES:CC(C)[C@@H]1COC(=N1)C(C)Cl

Technology Process of Oxazole, 2-(1-chloroethyl)-4,5-dihydro-4-(1-methylethyl)-, (4R)-

There total 1 articles about Oxazole, 2-(1-chloroethyl)-4,5-dihydro-4-(1-methylethyl)-, (4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4276-09-9,473-75-6
(R)-2-amino-3-methylbutanol

: 648428-09-5
(4R)-2-(1-chloroethyl)-4,5-dihydro-4-isopropyl-1,3-oxazole

Guidance literature:: Multi-step reaction with 2 steps

1: 1,2-dichloro-ethane / 70 °C

2: 85 percent / tert-butyl hypochlorite / CH₂Cl₂ / 0 °C

With tert-butylhypochlorite; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jo035360u

Reference yield: 93.0%

: 122778-03-4,137957-46-1
C-<4-(α,α,α-trifluoromethyl)phenyl>-N-tert-butylnitrone

: 648428-09-5
(4R)-2-(1-chloroethyl)-4,5-dihydro-4-isopropyl-1,3-oxazole

: (4R)-2-[(3R,4S)-2-tert-butyl-3-[4-(trifluoromethyl)phenyl]-4-methyl[1,2]oxazetidin-4-yl]-4-isopropyl-4,5-dihydro-1,3-oxazole

Guidance literature:: (4R)-2-(1-chloroethyl)-4,5-dihydro-4-isopropyl-1,3-oxazole; With lithium diisopropyl amide; In tetrahydrofuran; at -98 ℃; for 0.333333h;

C-<4-(α,α,α-trifluoromethyl)phenyl>-N-tert-butylnitrone; In tetrahydrofuran; at -98 - 20 ℃; for 3h;
DOI:10.1021/jo035360u

Reference yield: 90.0%

: 40117-30-4,137957-45-0
(Z)?N?(tert?butyl)?1?(4?chlorophenyl)methanimine oxide

: 648428-09-5
(4R)-2-(1-chloroethyl)-4,5-dihydro-4-isopropyl-1,3-oxazole

: (4R)-2-[(3R,4S)-2-tert-butyl-3-(4-chlorophenyl)-4-methyl[1,2]oxazetidin-4-yl]-4-isopropyl-4,5-dihydro-1,3-oxazole

Guidance literature:: (4R)-2-(1-chloroethyl)-4,5-dihydro-4-isopropyl-1,3-oxazole; With lithium diisopropyl amide; In tetrahydrofuran; at -98 ℃; for 0.333333h;

(Z)?N?(tert?butyl)?1?(4?chlorophenyl)methanimine oxide; In tetrahydrofuran; at -98 - 20 ℃; for 3h;
DOI:10.1021/jo035360u