Carbamic acid, [(1S)-1-[[[(1S)-3-[[(1R)-1-cyano-2-phenylethyl]amino]-2-hydroxy-3-oxo-1 -(phenylmethyl)propyl]amino]carbonyl]-3-methylbutyl]-, phenylmethyl ester

Base Information

• Chemical Name: Carbamic acid, [(1S)-1-[[[(1S)-3-[[(1R)-1-cyano-2-phenylethyl]amino]-2-hydroxy-3-oxo-1 -(phenylmethyl)propyl]amino]carbonyl]-3-methylbutyl]-, phenylmethyl ester
• CAS No.: 648433-93-6
• Molecular Formula: C33H38N4O5
• Molecular Weight: 570.689

Synonyms:

Chemical Property of Carbamic acid, [(1S)-1-[[[(1S)-3-[[(1R)-1-cyano-2-phenylethyl]amino]-2-hydroxy-3-oxo-1 -(phenylmethyl)propyl]amino]carbonyl]-3-methylbutyl]-, phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [(1S)-1-[[[(1S)-3-[[(1R)-1-cyano-2-phenylethyl]amino]-2-hydroxy-3-oxo-1 -(phenylmethyl)propyl]amino]carbonyl]-3-methylbutyl]-, phenylmethyl ester

There total 2 articles about Carbamic acid, [(1S)-1-[[[(1S)-3-[[(1R)-1-cyano-2-phenylethyl]amino]-2-hydroxy-3-oxo-1 -(phenylmethyl)propyl]amino]carbonyl]-3-methylbutyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

Z-Leu-OH (2018-66-8) + (S)-3-Amino-N-((R)-1-cyano-2-phenyl-ethyl)-2-hydroxy-4-phenyl-butyramide → 2(R)-[3(S)-(N-Cbz-L-leucylamino)-2(R,S)-hydroxy-4-phenylbutyrylamino]-3-phenylpropionitrile (648433-93-6)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jm0301336

Reference yield:

2(R)-[3(S)-(N-tert-butyloxycarbonylamino)-2(R,S)-hydroxy-4-phenylbutyrylamino]-3-phenylpropionitrile (648433-92-5) → 2(R)-[3(S)-(N-Cbz-L-leucylamino)-2(R,S)-hydroxy-4-phenylbutyrylamino]-3-phenylpropionitrile (648433-93-6)

Guidance literature:

Multi-step reaction with 2 steps

1: TFA

2: 84 percent / EDC; HOBT; NMM / dimethylformamide / 20 °C

With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In N,N-dimethyl-formamide;

DOI:10.1021/jm0301336

Reference yield: 92.0%

2(R)-[3(S)-(N-Cbz-L-leucylamino)-2(R,S)-hydroxy-4-phenylbutyrylamino]-3-phenylpropionitrile (648433-93-6) → 2(R)-[3(S)-(N-Cbz-L-leucylamino)-2(R,S)-hydroxy-4-phenylbutyrylamino]-1-amidino-3-phenylpropane (648433-94-7)

Guidance literature:

With N-Acetylcysteine; ammonium acetate; In methanol; at 50 ℃; for 16h;

DOI:10.1021/jm0301336

upstream raw materials:

Z-Leu-OH

2(R)-[3(S)-(N-tert-butyloxycarbonylamino)-2(R,S)-hydroxy-4-phenylbutyrylamino]-3-phenylpropionitrile

Downstream raw materials:

2(R)-[3(S)-(N-Cbz-L-leucylamino)-2(R,S)-hydroxy-4-phenylbutyrylamino]-1-amidino-3-phenylpropane

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 648433-93-6 Carbamic acid, [(1S)-1-[[[(1S)-3-[[(1R)-1-cyano-2-phenylethyl]amino]-2-hydroxy-3-oxo-1 -(phenylmethyl)propyl]amino]carbonyl]-3-methylbutyl]-, phenylmethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send