(3R)-3-[(4-Methylphenyl)sulfanyl]cyclohexan-1-one

Base Information

• Chemical Name: (3R)-3-[(4-Methylphenyl)sulfanyl]cyclohexan-1-one
• CAS No.: 64888-89-7
• Molecular Formula: C13H16OS
• Molecular Weight: 220.335
• DSSTox Substance ID: DTXSID70508366
• Nikkaji Number: J725.333H
• Wikidata: Q82365223
• Mol file: 64888-89-7.mol

Synonyms:64888-89-7;(3R)-3-[(4-Methylphenyl)sulfanyl]cyclohexan-1-one;DTXSID70508366

Chemical Property of (3R)-3-[(4-Methylphenyl)sulfanyl]cyclohexan-1-one

Chemical Property:

• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 220.09218630
• Heavy Atom Count: 15
• Complexity: 219

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)SC2CCCC(=O)C2
• Isomeric SMILES: CC1=CC=C(C=C1)S[C@@H]2CCCC(=O)C2

Technology Process of (3R)-3-[(4-Methylphenyl)sulfanyl]cyclohexan-1-one

There total 5 articles about (3R)-3-[(4-Methylphenyl)sulfanyl]cyclohexan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

cyclohexenone (930-68-7) + para-thiocresol (106-45-6) → 3-(p-tolylsulfanyl)cyclohexanone (64888-89-7,84658-22-0,104265-54-5,77670-22-5)

Guidance literature:

With perchloric acid; at 25 - 30 ℃; for 0.0333333h;

DOI:10.1016/j.tet.2006.11.050

Reference yield: 98.0%

cyclohexenone (930-68-7) + di(p-tolyl) disulfide (103-19-5) → 3-(p-tolylsulfanyl)cyclohexanone (64888-89-7,84658-22-0,104265-54-5,77670-22-5)

Guidance literature:

With rongalite; potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; chemoselective reaction;

DOI:10.1016/j.tet.2010.02.001

Reference yield: 82.0%

cyclohexenone (930-68-7) + p-toluenesulfonyl chloride (98-59-9) → 3-(p-tolylsulfanyl)cyclohexanone (64888-89-7,84658-22-0,104265-54-5,77670-22-5)

Guidance literature:

With rongalite; potassium carbonate; triphenylphosphine; In tetrahydrofuran; dimethyl sulfoxide; at 25 - 50 ℃;

upstream raw materials:

cyclohexenone

para-thiocresol

di(p-tolyl) disulfide

p-toluenesulfonyl chloride

Downstream raw materials:

3-[(4-methylphenyl)sulfanyl]phenol