4-(4-(HydroxyMethyl)phenoxy)phthalonitrile

Base Information

• Chemical Name: 4-(4-(HydroxyMethyl)phenoxy)phthalonitrile
• CAS No.: 649553-07-1
• Molecular Formula: C15H10N2O2
• Molecular Weight: 250.257
• Hs Code.: 2926909090
• Mol file: 649553-07-1.mol

Synonyms:4-[4-(hydroxymethyl)phenoxy]benzene-1,2-dicarbonitrile;

Chemical Property of 4-(4-(HydroxyMethyl)phenoxy)phthalonitrile

Chemical Property:

• PSA: 77.04000
• LogP: 2.71456
• Storage Temp.: 2-8°C

Purity/Quality:

99%min ^*data from raw suppliers

4-(4-(Hydroxymethyl)phenoxy)phthalonitrile 97 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-(HydroxyMethyl)phenoxy)phthalonitrile

There total 4 articles about 4-(4-(HydroxyMethyl)phenoxy)phthalonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(4-hydroxyphenyl)methanol (623-05-2) + 4-Nitrophthalonitrile (31643-49-9) → 4-[4-(hydroxymethyl)phenoxy]phthalonitrile (649553-07-1)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 40 ℃; for 10h;

DOI:10.1016/j.tetlet.2005.03.030

Reference yield:

4-Nitrophthalonitrile (31643-49-9) → 4-[4-(hydroxymethyl)phenoxy]phthalonitrile (649553-07-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide

2: sodium tetrahydroborate

With sodium tetrahydroborate; potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/j.inoche.2015.01.009

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-[4-(hydroxymethyl)phenoxy]phthalonitrile (649553-07-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide

2: sodium tetrahydroborate

With sodium tetrahydroborate; potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/j.inoche.2015.01.009

upstream raw materials:

(4-hydroxyphenyl)methanol

4-Nitrophthalonitrile

4-hydroxy-benzaldehyde

4-(4-formylphenoxy)-1,2-dicyanobenzene

Downstream raw materials:

4-[4-(methansulfonylmethyl)phenoxy]phthalonitrile

4-[4-(bromomethyl)phenoxy]phthalonitrile

zinc(II) phthalocyanine

Refernces

• 1、 Zhang, Liu,Wang, Ao,Lu, Shan,Zhou, Lin,Zhou, Jiahong,Lin, Yun,Wei, Shaohua. "The influences of the number of the ammonium groups and their arrangement manner on the photophysical properties of the quaternized zinc phthalocyanines". . p. 15 - 19. Retrieved 2015/01/30.
• 2、 Cosimelli, Barbara,Roncucci, Gabrio,Dei, Donata,Fantetti, Lia,Ferroni, Fiammetta,Ricci, Micaela,Spinelli, Domenico. "Synthesis and antimycotic activity of new unsymmetrical substituted zinc phthalocyanines". . p. 10025 - 10030. Retrieved 2007/10/03.