[4-(4-Hydroxyphenyl)phenyl]-phenylmethanone

Base Information

• Chemical Name: [4-(4-Hydroxyphenyl)phenyl]-phenylmethanone
• CAS No.: 5623-46-1
• Molecular Formula: C19H14O2
• Molecular Weight: 274.319
• NSC Number: 400770
• DSSTox Substance ID: DTXSID20322251
• Nikkaji Number: J1.074.342G
• Wikidata: Q27195907
• ChEMBL ID: CHEMBL1341020

Synonyms:MLS000757167;NSC 400770;5623-46-1;NSC400770;[4-(4-hydroxyphenyl)phenyl]-phenylmethanone;4-hydroxy-4'-benzoylbiphenyl;SCHEMBL2214895;CHEMBL1341020;4-(4-Hydroxyphenyl)benzophenone;DTXSID20322251;CHEBI:114504;NSC-400770;SMR000529026;(4'-hydroxy[1,1'-biphenyl]-4-yl)phenylmethanone;Q27195907

Chemical Property of [4-(4-Hydroxyphenyl)phenyl]-phenylmethanone

Chemical Property:

• Boiling Point: 457.9°Cat760mmHg
• Flash Point: 194.9°C
• Density: 1.186g/cm³
• XLogP3: 4.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 274.099379685
• Heavy Atom Count: 21
• Complexity: 330

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)C3=CC=C(C=C3)O

Technology Process of [4-(4-Hydroxyphenyl)phenyl]-phenylmethanone

There total 13 articles about [4-(4-Hydroxyphenyl)phenyl]-phenylmethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-Cyano-4'-hydroxybiphenyl (19812-93-2) + phenylmagnesium bromide → 4-(4'-hydroxyphenyl)benzophenone (5623-46-1)

Guidance literature:

4-Cyano-4'-hydroxybiphenyl; phenylmagnesium bromide; In tetrahydrofuran; for 3h; Heating;

With hydrogenchloride; In ethanol; for 3h; Heating;

DOI:10.1021/ja036808b

Reference yield: 95.0%

4-(4-methoxy-phenyl)-benzophenone (68294-33-7) → 4-(4'-hydroxyphenyl)benzophenone (5623-46-1)

Guidance literature:

With boron tribromide; at 20 ℃; for 2h;

DOI:10.1562/2005-02-17-RA-444

Reference yield: 33.0%

(4-bromophenyl)(phenyl)methanone (90-90-4) + tetramethylammonium phenoxide (36439-44-8) → benzophenone (119-61-9) + 4-(4'-hydroxyphenyl)benzophenone (5623-46-1) + 2-hydroxy-4'-benzoylbiphenyl (114746-23-5)

Guidance literature:

In dimethyl sulfoxide; at 20 ℃; electrochemical reduction;

DOI:10.1021/jo00242a029

upstream raw materials:

biphenyl 4-yl benzoate

4-(4-aminophenyl)-benzophenone

(4-bromophenyl)(phenyl)methanone

sodium phenoxide

Downstream raw materials:

4-(4-methoxy-phenyl)-benzophenone

4-(4'-hydroxyphenyl)-α-methylbenzhydrol

4-hydroxy-4'-(α-hydroxybenzyl)biphenyl

C₆H₅CHC₆H₄C₆H₄O

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