10.1016/S0960-894X(02)01003-X
The study focuses on the structure-activity relationships of novel anti-malarial agents, specifically N-(4-acylamino-3-benzoylphenyl)-[5-(4-nitrophenyl)-2furyl]acrylic acid amides. The researchers developed a lead compound, benzophenone 4g, which was modified by replacing the tolylacetyl residue at the 2-amino group with various acyl residues to determine their influence on anti-malarial activity. The chemicals used included 2-amino-5-nitrobenzophenone, acid chlorides for acylation, SnCl2?2H2O for reduction, and 3-[5-(4-nitrophenyl)-2-furyl]acrylic acid chloride for further acylation. The purpose of these chemicals was to synthesize and test a series of compounds to identify the optimal acyl residue structure for high anti-malarial activity, with the aim of overcoming drug resistance in Plasmodium falciparum, the causative agent of malaria. The study found that a phenylacetic acid substructure substituted in its para-position with methyl or similar-sized substituents was essential for high activity, with the trifluoromethyl-substituted derivative showing the most potent activity.
10.1039/c0ob01207f
The study investigates the structural effects on the photodissociation of alkoxyamines, which are compounds used in various fields including organic synthesis, fluorescence probes, and controlled polymerization processes. The researchers focused on the photochemical properties of six selected alkoxyamines, examining how their chemical structures influence the selectivity of bond cleavage and the efficiency of nitroxide formation. The alkoxyamines were studied using techniques such as ESR (Electron Spin Resonance) and laser flash photolysis to understand their behavior under light irradiation. Key chemicals used in the study include alkoxyamines with a benzophenone chromophore, which serves as a light-absorbing group, and various trapping agents to prevent back-reaction of radicals. The purpose of these chemicals was to investigate the photodissociation process and the generation of radicals, which are crucial for applications in photopolymerization and other photochemical reactions.
10.1002/ejoc.200900088
The study presents a novel and efficient method for synthesizing Vitamin E amines (tocopheramines and tocotrienamines) in enantiopure form. These compounds are significant due to their potential biological and antioxidant properties, making them valuable for applications in food additives, polymer stabilizers, and pharmaceuticals. The synthesis involves Pd-catalyzed N-arylation reactions on triflates derived from the corresponding phenols. Key chemicals used include Pd(OAc)2 and rac-BINAP as catalysts, NaOtBu or Cs2CO3 as bases, and benzylamine or benzophenone imine as nitrogen sources. The process involves converting natural tocopherols and tocotrienols into their triflate derivatives, followed by amination to introduce the nitrogen function at the 6-position of the chromane ring. The study optimizes the reaction conditions to achieve high yields and purity of the final products, demonstrating a significant improvement over previous methods. The synthesized compounds are of interest for further investigation into their antioxidant and therapeutic properties, with preliminary results showing promising antiproliferative effects on cancer cell lines.
10.1002/ejoc.202000612
The study explores a novel method for the direct exploitation of the ethynyl moiety in calcium carbide (CaC2) through sealed ball milling, which allows for the reaction of CaC2 with organic electrophiles without the need for additives or catalysts. The primary chemicals used in the study include calcium carbide (CaC2) and various ketones, such as benzophenone, 2-naphthyl phenyl ketone, 4,4′-dichlorobenzophenone, and others, which serve as substrates for ethynylation reactions. Additionally, aryl halides like 9-bromophenanthrene and 2-fluoro-1,4-dimethoxybenzene were used to investigate the feasibility of alkynylation under ball milling conditions. The purpose of these chemicals is to demonstrate a practical and cost-effective alternative method for introducing ethynyl functionalities into organic molecules, which is synthetically valuable and has potential applications in organic synthesis.
10.1021/om00135a016
The research focuses on the synthesis and characterization of organometallic compounds, specifically metallacycles and titanium-carbene complexes. The purpose of the study was to prepare a titanacyclobutane precursor, which was then reacted with benzophenone to yield an organic product, and further reacted with phosphines to obtain phosphine adducts of an α-substituted titanium-carbene complex. The researchers also succeeded in creating a heterobimetallic alkylidene complex by reacting the metallacycle with dimethylaluminum chloride. The conclusions drawn from the study indicate that the observed reactivity of the metallacycle is consistent with productive cleavage of the metal-containing ring, leading to the formation of titanium-carbene complexes. The chemicals used in the process include 3,3-dimethylcyclopropene, Tebbe reagent, (dimethylamino)pyridine (DMAP), benzophenone, phosphines (PMeR2, where R = Me, Ph), and dimethylaluminum chloride, among others. The study provides insights into the reactivity of metallacycles and their potential as precursors to titanium-carbene compounds.
10.1021/ja00367a016
The research investigates the kinetics of the hydrolysis of Schiff bases derived from benzophenone and various amines in aqueous solution. The purpose is to understand the mechanism of hydrolysis, particularly the role of intramolecular general-base catalysis by tertiary amino groups. The key chemicals used include Schiff bases such as benzophenone imine derivatives (la-j) with different substituents like aminoethyl, morpholine, piperazine, and pyridine groups. The study found that Schiff bases with an internal tertiary amino group at the p-position from the imino nitrogen atom showed significant intramolecular general-base catalysis of water attack on the protonated Schiff bases. The rate enhancement due to this intramolecular catalysis was correlated with the pKa of the internal catalyst, with effective concentrations of the internal bases estimated to range from 340 to 40 M. The research concludes that the enhanced reactivity in the hydrolysis of these Schiff bases is primarily due to intramolecular general-base catalysis by the tertiary amino groups, rather than other possible mechanisms such as nucleophilic participation through a 1,3-imidazolidinium intermediate.
10.1021/j100199a042
The photoreduction of benzophenone (BP) and N-methyldiphenylamine (MDPA) in acetonitrile solution was investigated using femtosecond-picosecond laser photolysis and time-resolved transient absorption spectroscopy. The formation and reactivity of ion pairs (IPs) generated by electron transfer (ET) between BP and MDPA were investigated, with a focus on the different reactivity differences based on the IP generation mode and the energy gaps of formation and recombination reactions. The results indicate that the reactivity of ion pairs, including charge recombination and proton transfer, depends largely on their generation pathways and the energy gaps involved.
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