Technology Process of Carbamic acid, dimethyl-,
1-[2-(4-chlorophenoxy)ethyl]-1,2,3,4-tetrahydro-6-isoquinolinyl ester
There total 8 articles about Carbamic acid, dimethyl-,
1-[2-(4-chlorophenoxy)ethyl]-1,2,3,4-tetrahydro-6-isoquinolinyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 7.56 g / POCl3 / 4 h / 80 °C
2: 4.88 g / H2; acetic acid / PtO2 / 3 h / 20 °C
3: 2.10 g / boron tribromide / CH2Cl2 / 3 h / 20 °C
4: 1.72 g / tetrahydrofuran / 1 h / 20 °C
5: 95 percent / K2CO3 / dimethylformamide / 2.5 h / 20 °C
6: 78 percent / LiAlH4 / tetrahydrofuran / 0.67 h / -78 - 0 °C
7: triphenylphosphine; diethyl azodicarboxylate / toluene; tetrahydrofuran / 1 h / 20 °C
8: HCl / ethyl acetate / 12 h / 20 °C
With
hydrogenchloride; lithium aluminium tetrahydride; hydrogen; boron tribromide; potassium carbonate; acetic acid; triphenylphosphine; diethylazodicarboxylate; trichlorophosphate;
platinum(IV) oxide;
In
tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
1: Bischler-Napieralski reaction / 7: Mitsunobu reaction;
DOI:10.1016/S0968-0896(03)00452-8
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 4.88 g / H2; acetic acid / PtO2 / 3 h / 20 °C
2: 2.10 g / boron tribromide / CH2Cl2 / 3 h / 20 °C
3: 1.72 g / tetrahydrofuran / 1 h / 20 °C
4: 95 percent / K2CO3 / dimethylformamide / 2.5 h / 20 °C
5: 78 percent / LiAlH4 / tetrahydrofuran / 0.67 h / -78 - 0 °C
6: triphenylphosphine; diethyl azodicarboxylate / toluene; tetrahydrofuran / 1 h / 20 °C
7: HCl / ethyl acetate / 12 h / 20 °C
With
hydrogenchloride; lithium aluminium tetrahydride; hydrogen; boron tribromide; potassium carbonate; acetic acid; triphenylphosphine; diethylazodicarboxylate;
platinum(IV) oxide;
In
tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
6: Mitsunobu reaction;
DOI:10.1016/S0968-0896(03)00452-8
![1-[2-(4-chloro-phenoxy)-ethyl]-6-dimethylcarbamoyloxy-3,4-dihydro-1<i>H</i>-isoquinoline-2-carboxylic acid <i>tert</i>-butyl ester](/Databaselist/images/loading.webp)
