2H-2-Benzazepine-2-carboxylic acid, 7-[[(dimethylamino)carbonyl]oxy]-1,3,4,5-tetrahydro-5-methylene-1-[2-(4 -nitrophenoxy)ethyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:2H-2-Benzazepine-2-carboxylic acid, 7-[[(dimethylamino)carbonyl]oxy]-1,3,4,5-tetrahydro-5-methylene-1-[2-(4 -nitrophenoxy)ethyl]-, 1,1-dimethylethyl ester
CAS No.:649722-88-3
Molecular Formula:C27H33N3O7
Molecular Weight:511.575
Hs Code.:

2H-2-Benzazepine-2-carboxylic acid,
7-[[(dimethylamino)carbonyl]oxy]-1,3,4,5-tetrahydro-5-methylene-1-[2-(4
-nitrophenoxy)ethyl]-, 1,1-dimethylethyl ester

Synonyms:

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Chemical Property of 2H-2-Benzazepine-2-carboxylic acid, 7-[[(dimethylamino)carbonyl]oxy]-1,3,4,5-tetrahydro-5-methylene-1-[2-(4 -nitrophenoxy)ethyl]-, 1,1-dimethylethyl ester

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MSDS Files:: SDS file from LookChem

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Technology Process of 2H-2-Benzazepine-2-carboxylic acid, 7-[[(dimethylamino)carbonyl]oxy]-1,3,4,5-tetrahydro-5-methylene-1-[2-(4 -nitrophenoxy)ethyl]-, 1,1-dimethylethyl ester

There total 1 articles about 2H-2-Benzazepine-2-carboxylic acid, 7-[[(dimethylamino)carbonyl]oxy]-1,3,4,5-tetrahydro-5-methylene-1-[2-(4 -nitrophenoxy)ethyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1779-49-3
Methyltriphenylphosphonium bromide

: 649722-87-2
7-dimethylcarbamoyloxy-1-[2-(4-nitrophenoxy)ethyl]-5-oxo-1,3,4,5-tetrahydrobenzo[c]azepine-2-carboxylic acid tert-butyl ester

: 649722-88-3
7-dimethylcarbamoyloxy-5-methylene-1-[2-(4-nitro-phenoxy)-ethyl]-1,3,4,5-tetrahydro-benzo[c]azepine-2-carboxylic acid tert-butyl ester

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; benzene; at 80 ℃; for 1h;
DOI:10.1016/S0968-0896(03)00452-8

Reference yield:

: 649722-88-3
7-dimethylcarbamoyloxy-5-methylene-1-[2-(4-nitro-phenoxy)-ethyl]-1,3,4,5-tetrahydro-benzo[c]azepine-2-carboxylic acid tert-butyl ester

: dimethyl-carbamic acid 5-methylene-1-[2-(4-nitro-phenoxy)-ethyl]-2,3,4,5-tetrahydro-1H-benzo[c]azepin-7-yl ester

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃; for 12h;
DOI:10.1016/S0968-0896(03)00452-8

Reference yield:

: 649722-88-3
7-dimethylcarbamoyloxy-5-methylene-1-[2-(4-nitro-phenoxy)-ethyl]-1,3,4,5-tetrahydro-benzo[c]azepine-2-carboxylic acid tert-butyl ester

: dimethylcarbamic acid 2-methyl-5-methylene-1-[2-(4-nitrophenoxy)ethyl]-2,3,4,5-tetrahydro-1H-benzo[c]azepin-7-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / ethyl acetate / 12 h / 20 °C

2: formic acid / H₂O / 3 h / 80 °C

With hydrogenchloride; formic acid; In water; ethyl acetate; 2: Eshweiler-Clarke reaction;
DOI:10.1016/S0968-0896(03)00452-8