2H-2-Benzazepine-2-carboxylic acid, 7-[[(dimethylamino)carbonyl]oxy]-1,3-dihydro-1-[2-(4-nitrophenoxy)ethyl] -5-[[(trifluoromethyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:2H-2-Benzazepine-2-carboxylic acid, 7-[[(dimethylamino)carbonyl]oxy]-1,3-dihydro-1-[2-(4-nitrophenoxy)ethyl] -5-[[(trifluoromethyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester
CAS No.:649722-91-8
Molecular Formula:C27H30F3N3O10S
Molecular Weight:645.611
Hs Code.:

2H-2-Benzazepine-2-carboxylic acid,
7-[[(dimethylamino)carbonyl]oxy]-1,3-dihydro-1-[2-(4-nitrophenoxy)ethyl]
-5-[[(trifluoromethyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester

Synonyms:

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Chemical Property of 2H-2-Benzazepine-2-carboxylic acid, 7-[[(dimethylamino)carbonyl]oxy]-1,3-dihydro-1-[2-(4-nitrophenoxy)ethyl] -5-[[(trifluoromethyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester

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MSDS Files:: SDS file from LookChem

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Technology Process of 2H-2-Benzazepine-2-carboxylic acid, 7-[[(dimethylamino)carbonyl]oxy]-1,3-dihydro-1-[2-(4-nitrophenoxy)ethyl] -5-[[(trifluoromethyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester

There total 12 articles about 2H-2-Benzazepine-2-carboxylic acid, 7-[[(dimethylamino)carbonyl]oxy]-1,3-dihydro-1-[2-(4-nitrophenoxy)ethyl] -5-[[(trifluoromethyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 145100-51-2
N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide

: 649722-87-2
7-dimethylcarbamoyloxy-1-[2-(4-nitrophenoxy)ethyl]-5-oxo-1,3,4,5-tetrahydrobenzo[c]azepine-2-carboxylic acid tert-butyl ester

: 649722-91-8
7-dimethylcarbamoyloxy-1-[2-(4-nitrophenoxy)ethyl]-5-trifluoromethanesulfonyloxy-1,3-dihydrobenzo[c]azepine-2-carboxylic acid tert-butyl ester

Guidance literature:: 7-dimethylcarbamoyloxy-1-[2-(4-nitrophenoxy)ethyl]-5-oxo-1,3,4,5-tetrahydrobenzo[c]azepine-2-carboxylic acid tert-butyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;

N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide; In tetrahydrofuran; at -78 ℃; for 1h;
DOI:10.1016/S0968-0896(03)00452-8

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 649722-91-8
7-dimethylcarbamoyloxy-1-[2-(4-nitrophenoxy)ethyl]-5-trifluoromethanesulfonyloxy-1,3-dihydrobenzo[c]azepine-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran; toluene / 1 h / 20 °C

1.2: HCl / ethyl acetate / 20 °C

2.1: 1.20 g / triethylamine / tetrahydrofuran / 1 h / 20 °C

3.1: LHMDS / tetrahydrofuran / 0.5 h / -78 °C

3.2: 98 percent / tetrahydrofuran / 1 h / -78 °C

With triethylamine; triphenylphosphine; lithium hexamethyldisilazane; diethylazodicarboxylate; In tetrahydrofuran; toluene; 1.1: Mitsunobu reaction;
DOI:10.1016/S0968-0896(03)00452-8

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 649722-91-8
7-dimethylcarbamoyloxy-1-[2-(4-nitrophenoxy)ethyl]-5-trifluoromethanesulfonyloxy-1,3-dihydrobenzo[c]azepine-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1.20 g / triethylamine / tetrahydrofuran / 1 h / 20 °C

2.1: LHMDS / tetrahydrofuran / 0.5 h / -78 °C

2.2: 98 percent / tetrahydrofuran / 1 h / -78 °C

With triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1016/S0968-0896(03)00452-8