Carbamic acid, dimethyl-, 5-ethenyl-2,3-dihydro-1-[2-(4-nitrophenoxy)ethyl]-1H-2-benzazepin-7-yl ester

Base Information

Chemical Name:Carbamic acid, dimethyl-, 5-ethenyl-2,3-dihydro-1-[2-(4-nitrophenoxy)ethyl]-1H-2-benzazepin-7-yl ester
CAS No.:649723-08-0
Molecular Formula:C₂₃H₂₅N₃O₅
Molecular Weight:423.469
Hs Code.:

Synonyms:

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Chemical Property of Carbamic acid, dimethyl-, 5-ethenyl-2,3-dihydro-1-[2-(4-nitrophenoxy)ethyl]-1H-2-benzazepin-7-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Carbamic acid, dimethyl-, 5-ethenyl-2,3-dihydro-1-[2-(4-nitrophenoxy)ethyl]-1H-2-benzazepin-7-yl ester

There total 15 articles about Carbamic acid, dimethyl-, 5-ethenyl-2,3-dihydro-1-[2-(4-nitrophenoxy)ethyl]-1H-2-benzazepin-7-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 649722-95-2
7-dimethylcarbamoyloxy-1-[2-(4-nitro-phenoxy)-ethyl]-5-vinyl-1,3-dihydro-benzo[c]azepine-2-carboxylic acid tert-butyl ester

: 649723-08-0
dimethyl-carbamic acid 1-[2-(4-nitro-phenoxy)-ethyl]-5-vinyl-2,3-dihydro-1H-benzo[c]azepin-7-yl ester

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃; for 12h;
DOI:10.1016/S0968-0896(03)00452-8

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 649723-08-0
dimethyl-carbamic acid 1-[2-(4-nitro-phenoxy)-ethyl]-5-vinyl-2,3-dihydro-1H-benzo[c]azepin-7-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran; toluene / 1 h / 20 °C

1.2: HCl / ethyl acetate / 20 °C

2.1: 1.20 g / triethylamine / tetrahydrofuran / 1 h / 20 °C

3.1: LHMDS / tetrahydrofuran / 0.5 h / -78 °C

3.2: 98 percent / tetrahydrofuran / 1 h / -78 °C

4.1: 65 percent / Pd₂(dba)3*CHCl₃; LiCl; Ph₃As / 1-methyl-pyrrolidin-2-one / 2 h / 20 °C

5.1: HCl / ethyl acetate / 12 h / 20 °C

With hydrogenchloride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; triphenyl-arsane; triethylamine; triphenylphosphine; lithium chloride; lithium hexamethyldisilazane; diethylazodicarboxylate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethyl acetate; toluene; 1.1: Mitsunobu reaction / 4.1: Stille reaction;
DOI:10.1016/S0968-0896(03)00452-8

Reference yield:

: 444646-66-6
dimethylcarbamic acid 4-formyl-3-vinylphenyl ester

: 649723-08-0
dimethyl-carbamic acid 1-[2-(4-nitro-phenoxy)-ethyl]-5-vinyl-2,3-dihydro-1H-benzo[c]azepin-7-yl ester

Guidance literature:: Multi-step reaction with 14 steps

1.1: lithium diisopropylamide / tetrahydrofuran; hexane / 0.33 h / -78 °C

1.2: 99 percent / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.1: 97 percent / LiBH₄ / tetrahydrofuran / 1 h / 20 °C

3.1: 70 percent / 4-dimethylaminopyridine; triethylamine / CH₂Cl₂ / 5 h / 20 °C

4.1: 78 percent / triphenylphosphine; carbon tetrabromide / CH₂Cl₂ / 1 h / 20 °C

5.1: 72 percent / acetonitrile / 12 h / 20 °C

6.1: 89 percent / triethylamine / tetrahydrofuran / 3 h / 50 °C

7.1: 96 percent / (1,3-dimesitylimidazolidin-2-yl)[P(c-hexyl)3]Ru(=CHPh)Cl₂ / CH₂Cl₂ / 3 h / 45 °C

8.1: 96 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

9.1: BH₃ / tetrahydrofuran / 15 h / 20 °C

9.2: NaBO₃*4H₂O / tetrahydrofuran; H₂O / 2 h / 20 °C

9.3: 1.87 g / manganese dioxide / CH₂Cl₂ / 2 h / 20 °C

10.1: triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran; toluene / 1 h / 20 °C

10.2: HCl / ethyl acetate / 20 °C

11.1: 1.20 g / triethylamine / tetrahydrofuran / 1 h / 20 °C

12.1: LHMDS / tetrahydrofuran / 0.5 h / -78 °C

12.2: 98 percent / tetrahydrofuran / 1 h / -78 °C

13.1: 65 percent / Pd₂(dba)3*CHCl₃; LiCl; Ph₃As / 1-methyl-pyrrolidin-2-one / 2 h / 20 °C

14.1: HCl / ethyl acetate / 12 h / 20 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; hydrogenchloride; dmap; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; lithium borohydride; carbon tetrabromide; triphenyl-arsane; borane; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; lithium chloride; lithium hexamethyldisilazane; lithium diisopropyl amide; diethylazodicarboxylate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; hexane; dichloromethane; ethyl acetate; toluene; acetonitrile; 10.1: Mitsunobu reaction / 13.1: Stille reaction;
DOI:10.1016/S0968-0896(03)00452-8