3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxylic acid

Base Information

Chemical Name:3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxylic acid
CAS No.:649757-53-9
Molecular Formula:C12H11NO3S
Molecular Weight:249.29
Hs Code.:
DSSTox Substance ID:DTXSID50602578
Wikidata:Q82499707

Synonyms:649757-53-9;3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxylic acid;SCHEMBL5193028;DTXSID50602578;OVZGEYCSYDYAAG-UHFFFAOYSA-N;AKOS000352612;DA-24248;EN300-144342;3-amino-5-(4-methoxyphenyl)-2-thiophenecarboxylic acid;3-amino-5-[4-(methyloxy)phenyl]-2-thiophenecarboxylic acid

Suppliers and Price of 3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxylic acid

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:249.04596439
Heavy Atom Count:17
Complexity:279

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2=CC(=C(S2)C(=O)O)N

Technology Process of 3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxylic acid

There total 3 articles about 3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 37572-23-9
3-amino-5-(4-methoxyphenyl)thiophene-2-carboxylic acid methyl ester

: 649757-53-9
3-amino-5-(4’-methoxyphenyl)thiophene-2-carboxylic acid

Guidance literature:: 3-amino-5-(4-methoxyphenyl)thiophene-2-carboxylic acid methyl ester; With potassium hydroxide; In ethanol; water; for 4h; Reflux;

With phosphoric acid; In water;
DOI:10.1055/s-0029-1218780

Reference yield:

: 57466-68-9
3-chloro-3-(4-methoxyphenyl)acrylonitrile

: 649757-53-9
3-amino-5-(4’-methoxyphenyl)thiophene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium; methanol / 0.5 h / Reflux

2: potassium hydroxide / methanol; water / 3 h / Reflux

With methanol; sodium; potassium hydroxide; In methanol; water;
DOI:10.1016/j.ejmech.2013.04.060

Reference yield:

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 649757-53-9
3-amino-5-(4’-methoxyphenyl)thiophene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / 0.25 h / 25 °C

1.2: 0.5 h / 20 - 60 °C

1.3: 0.5 h

2.1: sodium; methanol / 0.5 h / Reflux

3.1: potassium hydroxide / methanol; water / 3 h / Reflux

With methanol; sodium; potassium hydroxide; trichlorophosphate; In methanol; water;
DOI:10.1016/j.ejmech.2013.04.060