Uridine, 4-O-[2-(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)-, 5'-(2-cyano-1-phenylethyl carbonate) 3'-[2-(4-nitrophenyl)ethyl bis(1-methylethyl)phosphoramidite]

Base Information

Chemical Name:Uridine, 4-O-[2-(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)-, 5'-(2-cyano-1-phenylethyl carbonate) 3'-[2-(4-nitrophenyl)ethyl bis(1-methylethyl)phosphoramidite]
CAS No.:649759-89-7
Molecular Formula:C₄₇H₅₇N₆O₁₅P
Molecular Weight:976.975
Hs Code.:

Uridine,
4-O-[2-(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)-,
5'-(2-cyano-1-phenylethyl carbonate) 3'-[2-(4-nitrophenyl)ethyl
bis(1-methylethyl)phosphoramidite]

Synonyms:

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Chemical Property of Uridine, 4-O-[2-(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)-, 5'-(2-cyano-1-phenylethyl carbonate) 3'-[2-(4-nitrophenyl)ethyl bis(1-methylethyl)phosphoramidite]

Chemical Property:

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Safty Information:

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MSDS Files:: SDS file from LookChem

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Technology Process of Uridine, 4-O-[2-(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)-, 5'-(2-cyano-1-phenylethyl carbonate) 3'-[2-(4-nitrophenyl)ethyl bis(1-methylethyl)phosphoramidite]

There total 3 articles about Uridine, 4-O-[2-(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)-, 5'-(2-cyano-1-phenylethyl carbonate) 3'-[2-(4-nitrophenyl)ethyl bis(1-methylethyl)phosphoramidite] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17327-22-9
4-methoxy-2,6-dihydropyran

: 649759-89-7
5'-O-[(2-cyano-1-phenylethoxy)carbonyl]-O⁴-[2-(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)uridine 3'-2-(4-nitrophenyl)ethyl diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridinium p-toluenesulfonate / CH₂Cl₂ / 72 h / 20 °C

1.2: 59 percent / NH₄F / methanol / 96 h / 20 °C

2.1: 59 percent / pyridine / CH₂Cl₂ / -70 - -20 °C

3.1: 72 percent / 1H-tetrazole / CH₂Cl₂ / 18 h

With pyridine; 1H-tetrazole; pyridinium p-toluenesulfonate; In dichloromethane;
DOI:10.1002/hlca.200390206

Reference yield:

: 173169-01-2
O⁴-<2-(4-nitrophenyl)ethyl>-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

: 649759-89-7
5'-O-[(2-cyano-1-phenylethoxy)carbonyl]-O⁴-[2-(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)uridine 3'-2-(4-nitrophenyl)ethyl diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridinium p-toluenesulfonate / CH₂Cl₂ / 72 h / 20 °C

1.2: 59 percent / NH₄F / methanol / 96 h / 20 °C

2.1: 59 percent / pyridine / CH₂Cl₂ / -70 - -20 °C

3.1: 72 percent / 1H-tetrazole / CH₂Cl₂ / 18 h

With pyridine; 1H-tetrazole; pyridinium p-toluenesulfonate; In dichloromethane;
DOI:10.1002/hlca.200390206

Reference yield:

: 649759-66-0
O⁴-[2-(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)uridine

: 649759-89-7
5'-O-[(2-cyano-1-phenylethoxy)carbonyl]-O⁴-[2-(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)uridine 3'-2-(4-nitrophenyl)ethyl diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 2 steps

1: 59 percent / pyridine / CH₂Cl₂ / -70 - -20 °C

2: 72 percent / 1H-tetrazole / CH₂Cl₂ / 18 h

With pyridine; 1H-tetrazole; In dichloromethane;
DOI:10.1002/hlca.200390206