N-(4-Hydroxyphenylethyl)phthaliMide

Base Information

• Chemical Name: N-(4-Hydroxyphenylethyl)phthaliMide
• CAS No.: 64985-42-8
• Molecular Formula: C16H13NO3
• Molecular Weight: 267.284
• Mol file: 64985-42-8.mol

Synonyms:2-[2-(4-Hydroxyphenyl)ethyl]-1H-isoindole-1,3(2H)-dione;2-(4-hydroxyphenethyl)phthalimide;N-(4-Hydroxyphenylethyl)phthalimide;N-(4-hydroxy-phenethyl)-phthalimide;N-Phthaloyltyramine;2-[2-(4-Hydroxy-phenyl)-ethyl]-isoindole-1,3-dione;N-(4-Hydroxy-phenaethyl)-phthalimid;4-[2-(phthalimido)-ethyl]-phenol;

Chemical Property of N-(4-Hydroxyphenylethyl)phthaliMide

Chemical Property:

• PSA: 57.61000
• LogP: 2.16880

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-Hydroxyphenylethyl)phthaliMide

There total 17 articles about N-(4-Hydroxyphenylethyl)phthaliMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

tyrosamine (51-67-2) + phthalic anhydride (85-44-9) → 2-(2-(4-hydroxyphenyl)ethyl) isoindolin-1,3-dione (64985-42-8)

Guidance literature:

With acetic acid; In toluene; at 110 ℃; for 19h;

DOI:10.1021/acs.jmedchem.1c01388

Reference yield: 95.0%

N-phthaloyl-L-tyrosine (29588-94-1,6319-55-7) → 2-(2-(4-hydroxyphenyl)ethyl) isoindolin-1,3-dione (64985-42-8)

Guidance literature:

With potassium carbonate; In water; acetone; for 12h; Inert atmosphere; Irradiation;

DOI:10.3762/bjoc.7.60

Reference yield: 83.0%

tyrosamine (51-67-2) + carbon monoxide (201230-82-2) + 2,3-dibromobenzene (583-53-9) → 2-(2-(4-hydroxyphenyl)ethyl) isoindolin-1,3-dione (64985-42-8)

Guidance literature:

With palladium diacetate; triethylamine; catacxium A; In N,N-dimethyl acetamide; at 100 ℃; for 30h; under 22502.3 Torr; Autoclave; Inert atmosphere;

DOI:10.1039/c4ob00796d

upstream raw materials:

tyrosamine

phthalic anhydride

N-ethoxycarbonylphthalimide

2-[2-(7-Oxa-bicyclo[4.1.0]hepta-2,4-dien-3-yl)-ethyl]-isoindole-1,3-dione

Downstream raw materials:

4-{4-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-phenoxymethyl}-benzoic acid methyl ester

4-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)ethyl)-phenyl trifluoromethane-sulfonate

dichlorotyraminephthalimide

2-{2-[4-(Pyrrolidin-3-yloxy)-phenyl]-ethyl}-isoindole-1,3-dione; compound with trifluoro-acetic acid

Refernces

• 1、 Andrade-Jorge, Erik,Padilla-Martínez, Itzia I.,Ruiz-Maciel, Omar,Sánchez-Labastida, Luis A.,Soriano-Ursúa, Marvin A.,Trujillo-Ferrara, José G.. "Inhibitory activity on cholinesterases produced by aryl-phthalimide derivatives: green synthesis, in silico and in vitro evaluation". . . Retrieved 2020/05/08.
• 2、 Xiao, Bin,Wang, Shumin,She, Zhanfei,Cao, Qingfeng,Zhao, Na,Tian, Xiangrong,Su, Yixin. "Structure-based design, synthesis, PPAR-γ activation, and molecular docking of N-substituted phthalimides". . p. 1628 - 1634. Retrieved 2017/06/27.