Technology Process of Carbamic acid,
[(3R,5S)-5-[[(1,1-dimethylethoxy)carbonyl]amino]-3-fluoro-6-hydroxyhex
yl]-, phenylmethyl ester
There total 9 articles about Carbamic acid,
[(3R,5S)-5-[[(1,1-dimethylethoxy)carbonyl]amino]-3-fluoro-6-hydroxyhex
yl]-, phenylmethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium hydrogencarbonate;
In
acetone;
at 20 ℃;
for 1h;
DOI:10.1039/b307563j
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: NaH / tetrahydrofuran / 18 h / 20 °C
1.2: tetrahydrofuran / 5 h / 5 - 20 °C
1.3: 85 percent / tetrahydrofuran / 18 h
2.1: 100 percent / H2 / Pd/C / ethanol / 18 h / 20 °C / 3102.97 Torr
3.1: NaBH4 / methanol / -50 - 0 °C
4.1: 99 percent / K2CO3 / tetrahydrofuran / 48 h / 20 °C
5.1: 99 percent / TEA; MsCl; DMAP / CH2Cl2 / 1 h / -70 °C
6.1: 100 percent / NaBH4 / tetrahydrofuran; H2O / 3 h
7.1: 3.61 g / H2 / Pd/C / ethanol / 24 h / 3102.97 Torr
8.1: 100 percent / aq. AcOH / 72 h / 20 °C
9.1: 66 percent / aq. KHCO3 / acetone / 1 h / 20 °C
With
dmap; sodium tetrahydroborate; TEA; hydrogen; sodium hydride; potassium carbonate; potassium hydrogencarbonate; acetic acid; methanesulfonyl chloride;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetone;
1.2: Wadsworth-Emmons reaction / 1.3: Wadsworth-Emmons reaction / 4.1: Henry reaction;
DOI:10.1039/b307563j
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 99 percent / K2CO3 / tetrahydrofuran / 48 h / 20 °C
2: 99 percent / TEA; MsCl; DMAP / CH2Cl2 / 1 h / -70 °C
3: 100 percent / NaBH4 / tetrahydrofuran; H2O / 3 h
4: 3.61 g / H2 / Pd/C / ethanol / 24 h / 3102.97 Torr
5: 100 percent / aq. AcOH / 72 h / 20 °C
6: 66 percent / aq. KHCO3 / acetone / 1 h / 20 °C
With
dmap; sodium tetrahydroborate; TEA; hydrogen; potassium carbonate; potassium hydrogencarbonate; acetic acid; methanesulfonyl chloride;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane; water; acetone;
1: Henry reaction;
DOI:10.1039/b307563j
