Technology Process of 2,4(1H,3H)-Pyrimidinedione,
1-[(2R,4R,5R)-4-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]tetrahydro-
5-[2-(triphenylmethoxy)ethyl]-2-furanyl]-5-methyl-
There total 9 articles about 2,4(1H,3H)-Pyrimidinedione,
1-[(2R,4R,5R)-4-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]tetrahydro-
5-[2-(triphenylmethoxy)ethyl]-2-furanyl]-5-methyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
2,4,6-trimethyl-pyridine; tetrabutylammonium perchlorate;
In
dichloromethane;
at 20 ℃;
for 5h;
DOI:10.1002/hlca.200390243
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 96 percent / H2; quinoline / Lindlar catalyst / ethyl acetate
2.1: tetraisopropyl orthotitanate; (+)-diisopropyl L-tartrate; t-BuOOH / CH2Cl2 / -50 - -20 °C
2.2: 4.0 g / diethyl ether; tetrahydrofuran / 1 h / -50 °C
3.1: 87 percent / pyridine / CH2Cl2 / 20 °C
4.1: osmium tetroxide; 4-methylmorpholine 4-oxide / tetrahydrofuran; H2O; 2-methyl-propan-2-ol / 20 °C
5.1: sodium metaperiodate / tetrahydrofuran; H2O / 0.5 h
6.1: 6.2 g / Dowex 50*8 / 1.5 h / 20 °C
7.1: 98 percent / H2 / 10 percent Pd/C / methanol / 4 h
8.1: 32 percent / N-methyl-N-(trimethylsilyl)trifluoroacetamide; trimethylsilyl triflate / acetonitrile / 8 h / 20 °C
9.1: 94 percent / tetrabutylammonium perchlorate; 2,4,6-collidine / CH2Cl2 / 5 h / 20 °C
With
pyridine; 2,4,6-trimethyl-pyridine; quinoline; titanium(IV) isopropylate; tert.-butylhydroperoxide; sodium periodate; osmium(VIII) oxide; L-(+)-diisopropyl tartrate; trimethylsilyl trifluoromethanesulfonate; Dowex 50*8; N-methyl-N-trimethylsilyl-2,2,2-trifluoroacetamide; tetrabutylammonium perchlorate; hydrogen; 4-methylmorpholine N-oxide;
palladium on activated charcoal; Lindlar's catalyst;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; acetonitrile; tert-butyl alcohol;
DOI:10.1002/hlca.200390243
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: tetraisopropyl orthotitanate; (+)-diisopropyl L-tartrate; t-BuOOH / CH2Cl2 / -50 - -20 °C
1.2: 4.0 g / diethyl ether; tetrahydrofuran / 1 h / -50 °C
2.1: 87 percent / pyridine / CH2Cl2 / 20 °C
3.1: osmium tetroxide; 4-methylmorpholine 4-oxide / tetrahydrofuran; H2O; 2-methyl-propan-2-ol / 20 °C
4.1: sodium metaperiodate / tetrahydrofuran; H2O / 0.5 h
5.1: 6.2 g / Dowex 50*8 / 1.5 h / 20 °C
6.1: 98 percent / H2 / 10 percent Pd/C / methanol / 4 h
7.1: 32 percent / N-methyl-N-(trimethylsilyl)trifluoroacetamide; trimethylsilyl triflate / acetonitrile / 8 h / 20 °C
8.1: 94 percent / tetrabutylammonium perchlorate; 2,4,6-collidine / CH2Cl2 / 5 h / 20 °C
With
pyridine; 2,4,6-trimethyl-pyridine; titanium(IV) isopropylate; tert.-butylhydroperoxide; sodium periodate; osmium(VIII) oxide; L-(+)-diisopropyl tartrate; trimethylsilyl trifluoromethanesulfonate; Dowex 50*8; N-methyl-N-trimethylsilyl-2,2,2-trifluoroacetamide; tetrabutylammonium perchlorate; hydrogen; 4-methylmorpholine N-oxide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; water; acetonitrile; tert-butyl alcohol;
DOI:10.1002/hlca.200390243
