Carbamic acid, [(1R)-2-[[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy]-1-[[[(1,1-dimethyl ethyl)diphenylsilyl]oxy]methyl]ethyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [(1R)-2-[[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy]-1-[[[(1,1-dimethyl ethyl)diphenylsilyl]oxy]methyl]ethyl]-, 1,1-dimethylethyl ester
CAS No.:651031-09-3
Molecular Formula:C30H45NO6Si
Molecular Weight:543.776
Hs Code.:

Carbamic acid,
[(1R)-2-[[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy]-1-[[[(1,1-dimethyl
ethyl)diphenylsilyl]oxy]methyl]ethyl]-, 1,1-dimethylethyl ester

Synonyms:

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Chemical Property of Carbamic acid, [(1R)-2-[[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy]-1-[[[(1,1-dimethyl ethyl)diphenylsilyl]oxy]methyl]ethyl]-, 1,1-dimethylethyl ester

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Technology Process of Carbamic acid, [(1R)-2-[[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy]-1-[[[(1,1-dimethyl ethyl)diphenylsilyl]oxy]methyl]ethyl]-, 1,1-dimethylethyl ester

There total 4 articles about Carbamic acid, [(1R)-2-[[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy]-1-[[[(1,1-dimethyl ethyl)diphenylsilyl]oxy]methyl]ethyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 76679-39-5
[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl trifluoromethanesulfonate

: 198417-69-5
tert-butyl [(1R)-2-(tert-butyldiphenylsilyloxy)-1-(hydroxymethyl)-ethyl]carbamate

: 651031-09-3
(2R)-2-(tert-butoxycarbonylamino)-3-(tert-butyldiphenylsilyloxy)propanoxy-(4S)-methyl-2,2-dimethyl-[1,3]-dioxolane

Guidance literature:: tert-butyl [(1R)-2-(tert-butyldiphenylsilyloxy)-1-(hydroxymethyl)-ethyl]carbamate; With sodium hydride; In tetrahydrofuran; for 0.25h; cooling;

[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl trifluoromethanesulfonate; In tetrahydrofuran; for 2.16667h;
DOI:10.1021/ol035998s

Reference yield:

: 2766-43-0
N-tert-butyloxycarbonyl-L-serine methyl ester

: 651031-09-3
(2R)-2-(tert-butoxycarbonylamino)-3-(tert-butyldiphenylsilyloxy)propanoxy-(4S)-methyl-2,2-dimethyl-[1,3]-dioxolane

Guidance literature:: Multi-step reaction with 3 steps

1.1: 95 percent / imidazole / dimethylformamide / 2 h / 20 °C

2.1: 92 percent / LiBH₄ / diethyl ether / 0 - 20 °C

3.1: NaH / tetrahydrofuran / 0.25 h / cooling

3.2: 83 percent / tetrahydrofuran / 2.17 h

With 1H-imidazole; lithium borohydride; sodium hydride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/ol035998s

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 651031-09-3
(2R)-2-(tert-butoxycarbonylamino)-3-(tert-butyldiphenylsilyloxy)propanoxy-(4S)-methyl-2,2-dimethyl-[1,3]-dioxolane

Guidance literature:: Multi-step reaction with 3 steps

1.1: 95 percent / imidazole / dimethylformamide / 2 h / 20 °C

2.1: 92 percent / LiBH₄ / diethyl ether / 0 - 20 °C

3.1: NaH / tetrahydrofuran / 0.25 h / cooling

3.2: 83 percent / tetrahydrofuran / 2.17 h

With 1H-imidazole; lithium borohydride; sodium hydride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/ol035998s