1-Pyrrolidinecarboxylic acid, 2-(10-oxodecyl)-3,4-bis(phenylmethoxy)-5-[(phenylmethoxy)methyl]-, 1,1-dimethylethyl ester, (2R,3R,4R,5R)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 2-(10-oxodecyl)-3,4-bis(phenylmethoxy)-5-[(phenylmethoxy)methyl]-, 1,1-dimethylethyl ester, (2R,3R,4R,5R)-
CAS No.:651321-48-1
Molecular Formula:C₄₁H₅₅NO₆
Molecular Weight:657.891
Hs Code.:

1-Pyrrolidinecarboxylic acid,
2-(10-oxodecyl)-3,4-bis(phenylmethoxy)-5-[(phenylmethoxy)methyl]-,
1,1-dimethylethyl ester, (2R,3R,4R,5R)-

Synonyms:

Suppliers and Price of 1-Pyrrolidinecarboxylic acid, 2-(10-oxodecyl)-3,4-bis(phenylmethoxy)-5-[(phenylmethoxy)methyl]-, 1,1-dimethylethyl ester, (2R,3R,4R,5R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Pyrrolidinecarboxylic acid, 2-(10-oxodecyl)-3,4-bis(phenylmethoxy)-5-[(phenylmethoxy)methyl]-, 1,1-dimethylethyl ester, (2R,3R,4R,5R)-

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Pyrrolidinecarboxylic acid, 2-(10-oxodecyl)-3,4-bis(phenylmethoxy)-5-[(phenylmethoxy)methyl]-, 1,1-dimethylethyl ester, (2R,3R,4R,5R)-

There total 19 articles about 1-Pyrrolidinecarboxylic acid, 2-(10-oxodecyl)-3,4-bis(phenylmethoxy)-5-[(phenylmethoxy)methyl]-, 1,1-dimethylethyl ester, (2R,3R,4R,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 651321-47-0
(2R,3R,4R,5R)-N-[(1,1-dimethylethoxy)carbonyl]-2-[(phenylmethoxy)methyl]-3,4-bis(phenylmethyloxy)-5-(1,2-dihydroxyundecan-11-yl)pyrrolidine

: 651321-48-1
(2R,3R,4R,5R)-N-[(1,1-dimethylethoxy)carbonyl]-2-[(phenylmethoxy)methyl]-3,4-bis(phenylmethyloxy)-5-(1-oxodecan-11-yl)pyrrolidine

Guidance literature:: With sodium periodate; In diethyl ether; water; at 20 ℃; for 2h;
DOI:10.1081/CAR-120026470

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 651321-48-1
(2R,3R,4R,5R)-N-[(1,1-dimethylethoxy)carbonyl]-2-[(phenylmethoxy)methyl]-3,4-bis(phenylmethyloxy)-5-(1-oxodecan-11-yl)pyrrolidine

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / Et₃N / tetrahydrofuran / 0.03 h / 0 - 20 °C

2: Et₃N / CH₂Cl₂ / 1.58 h / 0 - 20 °C

3: t-BuOK / tetrahydrofuran; CH₂Cl₂ / 18 h / 20 °C

4: K₂OsO₄*2H₂O; NMO / acetone; H₂O / 3 h / 20 °C

5: NaIO₄ / diethyl ether; H₂O / 2 h / 20 °C

With potassium osmate(VI); sodium periodate; N-methyl-2-indolinone; potassium tert-butylate; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetone;
DOI:10.1081/CAR-120026470

Reference yield:

: 1125-88-8
benzaldehyde dimethyl acetal

: 651321-48-1
(2R,3R,4R,5R)-N-[(1,1-dimethylethoxy)carbonyl]-2-[(phenylmethoxy)methyl]-3,4-bis(phenylmethyloxy)-5-(1-oxodecan-11-yl)pyrrolidine

Guidance literature:: Multi-step reaction with 12 steps

1: 70 percent / p-TsOH / CH₂Cl₂ / 1 h / -20 - 10 °C

2: CH₂Cl₂ / 1.58 h / 0 - 20 °C

3: 80 percent / NaN₃ / dimethylformamide / 18 h / 60 °C

4: 89 percent / AlCl₃; BH₃*NMe₃ / tetrahydrofuran / 3 h / 0 °C

5: 88 percent / PPh₃; DEAD / tetrahydrofuran / 18 h / 20 °C

6: 85 percent / PPh₃; H₂O / tetrahydrofuran / 4 h / 60 °C

7: 76 percent / NaOH / methanol / 0 - 20 °C

8: 80 percent / Et₃N / tetrahydrofuran / 0.03 h / 0 - 20 °C

9: Et₃N / CH₂Cl₂ / 1.58 h / 0 - 20 °C

10: t-BuOK / tetrahydrofuran; CH₂Cl₂ / 18 h / 20 °C

11: K₂OsO₄*2H₂O; NMO / acetone; H₂O / 3 h / 20 °C

12: NaIO₄ / diethyl ether; H₂O / 2 h / 20 °C

With sodium hydroxide; potassium osmate(VI); sodium periodate; aluminium trichloride; sodium azide; N-methyl-2-indolinone; trimethylamine-borane; potassium tert-butylate; water; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetone; 5: Mitsunobu reaction / 6: Staudinger reduction;
DOI:10.1081/CAR-120026470