Phenyl (4-ethoxyphenyl)carbamate

Base Information

• Chemical Name: Phenyl (4-ethoxyphenyl)carbamate
• CAS No.: 65141-22-2
• Molecular Formula: C15H15NO3
• Molecular Weight: 257.289
• DSSTox Substance ID: DTXSID20608062
• Wikidata: Q82507169
• Mol file: 65141-22-2.mol

Synonyms:Phenyl (4-ethoxyphenyl)carbamate;65141-22-2;SCHEMBL11185563;DTXSID20608062;AKOS008918042

Chemical Property of Phenyl (4-ethoxyphenyl)carbamate

Chemical Property:

• XLogP3: 3.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 257.10519334
• Heavy Atom Count: 19
• Complexity: 269

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC=C(C=C1)NC(=O)OC2=CC=CC=C2

Technology Process of Phenyl (4-ethoxyphenyl)carbamate

There total 2 articles about Phenyl (4-ethoxyphenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.2%

→ phenyl N-(4-ethoxyphenyl)carbamate (65141-22-2)

Guidance literature:

With potassium carbonate; In dichloromethane; at 0 - 20 ℃; for 3.25h;

Reference yield:

4-Ethoxyaniline (156-43-4) + phenyl chloroformate (1885-14-9) → phenyl N-(4-ethoxyphenyl)carbamate (65141-22-2)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 4h; Cooling with ice;

DOI:10.3390/molecules16064527

Reference yield:

phenyl N-(4-ethoxyphenyl)carbamate (65141-22-2) → 4-(4-ethoxy-phenyl)-semicarbazide (74099-07-3)

Guidance literature:

With hydrazine hydrate; for 12h; Reflux;

DOI:10.3390/molecules16064527

upstream raw materials:

4-Ethoxyaniline

phenyl chloroformate

Downstream raw materials:

4-[(10S)-dihydroartemisinin-10-oxy]benzaldehyde N₄-(4-ethoxyphenyl)semicarbazone

4-[(10S)-dihydroartemisinin-10-oxycarbonyl]benzaldehyde N₄-(4-ethoxyphenyl)semicarbazone

4-(4-ethoxy-phenyl)-semicarbazide