2-Hydroxy-3,5-dimethoxybenzaldehyde

Base Information

• Chemical Name: 2-Hydroxy-3,5-dimethoxybenzaldehyde
• CAS No.: 65162-29-0
• Molecular Formula: C9H10O4
• Molecular Weight: 182.176
• DSSTox Substance ID: DTXSID50428270
• Nikkaji Number: J1.485.872E
• Wikidata: Q82241082
• Mol file: 65162-29-0.mol

Synonyms:2-hydroxy-3,5-dimethoxybenzaldehyde;65162-29-0;2-Hydroxy-3,5-dimethoxy-benzaldehyde;Benzaldehyde, 2-hydroxy-3,5-dimethoxy-;3,5-di-methoxy-hydroxybenzaldehyde;3,5-Dimethoxy-salicylaldehyd;SCHEMBL118908;DTXSID50428270;RZKNKVRCIXKLBQ-UHFFFAOYSA-N;3,5-Dimethoxy-2-hydroxybenzaldehyde;AKOS006292361;Benzaldehyde,2-hydroxy-3,5-dimethoxy

Chemical Property of 2-Hydroxy-3,5-dimethoxybenzaldehyde

Chemical Property:

• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 182.05790880
• Heavy Atom Count: 13
• Complexity: 171

Purity/Quality:

99.3% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C(=C1)OC)O)C=O

Technology Process of 2-Hydroxy-3,5-dimethoxybenzaldehyde

There total 10 articles about 2-Hydroxy-3,5-dimethoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-bromo-3,5-dimethoxy-benzaldehyde (85565-93-1) → 3,5-Dimethoxy-2-hydroxybenzaldehyde (65162-29-0)

Guidance literature:

With water; copper; sodium hydroxide; for 24h; Reflux;

DOI:10.1016/j.tetlet.2012.08.138

Reference yield: 68.0%

3,5-dimethoxybenzaldehdye (7311-34-4) → 3,5-Dimethoxy-2-hydroxybenzaldehyde (65162-29-0)

Guidance literature:

With C₂₈H₄₆N₄O₁₀S₂; dihydrogen peroxide; acetic acid; iron(II) chloride; In water; acetonitrile; at 80 ℃; for 1h; regioselective reaction;

DOI:10.1126/science.abj0731

Reference yield: 48.0%

→ 3,5-Dimethoxy-2-hydroxybenzaldehyde (65162-29-0)

Guidance literature:

With phthaloyl peroxide; Heating;

With sodium hydrogencarbonate; In methanol; water; for 12h; Inert atmosphere;

upstream raw materials:

chloroform

2,4-dimethoxyphenol

2-bromo-3,5-dimethoxy-benzaldehyde

3,5-dimethoxybenzyl alcohol

Downstream raw materials:

C₁₈H₁₅NO₅

3-(3',4',5'-trihydroxyphenyl)-6,8-dihydroxycoumarin

2-(2,2-diethoxyethoxy)-3,5-dimethoxybenzaldehyde

2-bromo-3,5-dimethoxy-6-hydroxy-toluene