Benzamide, 4-amino-5-chloro-N-(8-(2-furanylmethyl)-8-azabicyclo(3.2.1)oct-3-yl)-2-methoxy-, exo-

Base Information

Chemical Name:Benzamide, 4-amino-5-chloro-N-(8-(2-furanylmethyl)-8-azabicyclo(3.2.1)oct-3-yl)-2-methoxy-, exo-
CAS No.:76352-16-4
Molecular Formula:C20H24ClN3O3
Molecular Weight:389.882
Hs Code.:
DSSTox Substance ID:DTXSID20997741

Synonyms:76352-16-4;Benzamide, 4-amino-5-chloro-N-(8-(2-furanylmethyl)-8-azabicyclo(3.2.1)oct-3-yl)-2-methoxy-, exo-;DTXSID20997741;LS-25439;4-Amino-5-chloro-N-{8-[(furan-2-yl)methyl]-8-azabicyclo[3.2.1]octan-3-yl}-2-methoxybenzene-1-carboximidic acid

Suppliers and Price of Benzamide, 4-amino-5-chloro-N-(8-(2-furanylmethyl)-8-azabicyclo(3.2.1)oct-3-yl)-2-methoxy-, exo-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzamide, 4-amino-5-chloro-N-(8-(2-furanylmethyl)-8-azabicyclo(3.2.1)oct-3-yl)-2-methoxy-, exo-

Chemical Property:

Vapor Pressure:5.1E-11mmHg at 25°C
Boiling Point:522.6°C at 760 mmHg
Flash Point:269.9°C
Density:1.34g/cm³
XLogP3:2.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:389.1506193
Heavy Atom Count:27
Complexity:523

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=C(C=C1C(=O)NC2CC3CCC(C2)N3CC4=CC=CO4)Cl)N

Technology Process of Benzamide, 4-amino-5-chloro-N-(8-(2-furanylmethyl)-8-azabicyclo(3.2.1)oct-3-yl)-2-methoxy-, exo-

There total 4 articles about Benzamide, 4-amino-5-chloro-N-(8-(2-furanylmethyl)-8-azabicyclo(3.2.1)oct-3-yl)-2-methoxy-, exo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.8%

: 7206-70-4
4-amino-5-chloro-2-methoxybenzoic acid

: 1335036-28-6
8-(furan-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3β-ylamine

: 76352-16-4
N-(8-(furan-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3β-yl)-4-amino-5-chloro-2-methoxybenzamide

Guidance literature:: 4-amino-5-chloro-2-methoxybenzoic acid; With chloroformic acid ethyl ester; triethylamine; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

8-(furan-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3β-ylamine; In N,N-dimethyl-formamide; for 24h;
DOI:10.1016/j.ejmech.2011.07.022

Reference yield:

: 617-89-0
furan-2-ylmethanamine

: 76352-16-4
N-(8-(furan-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3β-yl)-4-amino-5-chloro-2-methoxybenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / water / 1.25 h / 50 °C

1.2: 24 h / pH 4

2.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol; water / 24.5 h / 20 °C / Reflux

3.1: sodium / ethanol / 4 h / Reflux

4.1: chloroformic acid ethyl ester; triethylamine / N,N-dimethyl-formamide / 0.5 h / 0 °C

4.2: 24 h

With hydrogenchloride; hydroxylamine hydrochloride; sodium; chloroformic acid ethyl ester; sodium hydrogencarbonate; triethylamine; In ethanol; water; N,N-dimethyl-formamide; 3.1: Bouveault-Blanc reduction;
DOI:10.1016/j.ejmech.2011.07.022

Reference yield:

: 1335036-20-8
8-(furan-2-ylmethyl)-8-azabicyclo[3.2.1]octan-3-one

: 76352-16-4
N-(8-(furan-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3β-yl)-4-amino-5-chloro-2-methoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol; water / 24.5 h / 20 °C / Reflux

2.1: sodium / ethanol / 4 h / Reflux

3.1: chloroformic acid ethyl ester; triethylamine / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 24 h

With hydroxylamine hydrochloride; sodium; chloroformic acid ethyl ester; sodium hydrogencarbonate; triethylamine; In ethanol; water; N,N-dimethyl-formamide; 2.1: Bouveault-Blanc reduction;
DOI:10.1016/j.ejmech.2011.07.022