7206-70-4

Basic information

• Product Name: 4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACID
• Synonyms: 4-AMino-5-chloro-2-Methoxybenzoic acid, 98+% 25GR;5-Chloro-4-aMino-2-ethoxybenzoic acid;5-Chloro-4-aMino-2-Methoxybenzoic Acid;Benzoic acid, 4-aMino-5-chloro-2-Methoxy-;MetoclopraMide IMpurity C;4-Amino-5-chloro-2-methoxybenzoic acid 97%;340871_ALDRICH;A1961/0082485
• CAS NO: 7206-70-4
• Molecular Formula: C₈H₈ClNO₃
• Molecular Weight: 201.61
• EINECS: 230-582-3
• Product Categories: Pharmaceutical Intermediates;Amines;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Amines, Metabolites & Impurities, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Organic acids
• Mol File: 7206-70-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 206 °C (dec.)(lit.)
• Boiling Point: 369.7 °C at 760 mmHg
• Flash Point: 177.4 °C
• Appearance: White to slightly beige/Powder
• Density: 1.3639 (rough estimate)
• Vapor Pressure: 4.06E-06mmHg at 25°C
• Refractive Index: 1.5800 (estimate)
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 4.38±0.10(Predicted)
• CAS DataBase Reference: 4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACID(7206-70-4)
• EPA Substance Registry System: 4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACID(7206-70-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 7206-70-4(Hazardous Substances Data)

Usage

Chemical Properties

WHITE TO SLIGHTLY BEIGE POWDER

Uses

Different sources of media describe the Uses of 7206-70-4 differently. You can refer to the following data:
1. Metoclopramide (M338685) metabolite.
2. 4-Amino-5-chloro-2-methoxybenzoic Acid (Metoclopramide EP Impurity C) is a Metoclopramide (M338685) metabolite.

InChI:InChI=1/C8H8ClNO3/c1-13-7-3-6(10)5(9)2-4(7)8(11)12/h2-3H,10H2,1H3,(H,11,12)/p-1

Upstream product

• 20896-27-9 methyl 4-amino-5-chloro-2-methoxybenzoate 
• 4136-97-4 methyl 4-aminosalicylate 
• 65-49-6 4-Aminosalicylic acid 
• 4093-28-1 methyl 4-acetamido-2-hydroxybenzoate 
• 4093-29-2 methyl 4-(acetylamino)-o-anisate 
• 24201-13-6 4-(acetylamino)-5-chloro-2-methoxybenzoic acid 
• 4093-31-6 methyl 2-methoxy 4-acetamido 5-chloro benzoate 
• 27492-84-8 Methyl 4-amino-2-methoxybenzoate 

Downstream Products

• 126645-66-7 (4-benzyl-2-morpholinyl)methyl 4-amino-5-chloro-2-methoxybenzoate 
• 126645-67-8 5-amino-N-<(4-benzyl-2-morpholinyl)methyl>-5-chloro-2-methoxy-N-methylbenzamide 
• 112885-23-1 4-amino-N-<(4-benzyl-2-morpholinyl)methyl>-5-chloro-2-methoxybenzamide 
• 126645-68-9 4-amino-N-[2-(4-benzyl-2-morpholinyl)ethyl]-5-chloro-2-methoxybenzamide 
• 126645-70-3 4-amino-N-[3-(4-benzyl-2-morpholinyl)propyl]-5-chloro-2-methoxybenzamide 
• 112885-36-6 4-amino-5-chloro-N-<<4-(ethoxycarbonyl)-2-morpholinyl>methyl>-2-methoxybenzamide 
• 112884-96-5 4-Amino-5-chloro-2-methoxy-N-(4-phenethyl-morpholin-2-ylmethyl)-benzamide 
• 112884-94-3 4-Amino-5-chloro-2-methoxy-N-[4-(1-phenyl-ethyl)-morpholin-2-ylmethyl]-benzamide 
• 112884-98-7 4-Amino-5-chloro-2-methoxy-N-[4-(4-nitro-benzyl)-morpholin-2-ylmethyl]-benzamide 
• 112884-92-1 4-Amino-5-chloro-N-{4-[1-(4-fluoro-phenyl)-ethyl]-morpholin-2-ylmethyl}-2-methoxy-benzamide 
• 112885-32-2 4-amino-5-chloro-N-[[4-(4-cyanobenzyl)-2-morpholinyl]methyl]-2-methoxybenzamide 
• 112885-02-6 4-Amino-5-chloro-2-methoxy-N-[4-(4-methoxy-benzyl)-morpholin-2-ylmethyl]-benzamide 
• 112885-13-9 4-Amino-5-chloro-N-[4-(3,4-dichloro-benzyl)-morpholin-2-ylmethyl]-2-methoxy-benzamide 
• 112884-99-8 4-Amino-5-chloro-N-[4-(3-cyano-benzyl)-morpholin-2-ylmethyl]-2-methoxy-benzamide 

Relevant articles and documents

Synthetic method of 4-amino-5-chloro-2-methoxyl benzoic acid

The invention discloses a synthetic method of 4-amino-5-chloro-2-methoxyl benzoic acid, wherein the synthetic method includes the steps of dimethyl sulphate methylation, N-chloro-succinimide chlorination, alkaline hydrolysis de-esterification and hydrochloric acid acidification to prepare an intermediate product, wherein aminosalicylic acid, which is low in cost and easy to obtain, is employed as a raw material. The synthetic method is reasonable and simple in process route design, is mild in reaction conditions, is easy to industrially operate, is low in costs of raw material and devices, is high in yield and product quality, and is effectively reduced in production cost.

SYNTHESIS

The present invention relates to an improved process for the production of [(±)-endo]-4-amino-5-chloro-2-methoxy-N-(I-azabicyclo[3.3. 1]non-4-yl)benzamide hydrochloride, and intermediates thereof.

A CONVENIENT SYNTHESIS OF METHYL 4-AMINO-5-CHLORO-2-METHOXYBENZOATE

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