Technology Process of Carbamic acid,
[(2R,3S)-1-[bis(trimethylsilyl)methyl]-2-(2-methylpropyl)-4-oxo-3-(phenyl
methyl)-3-azetidinyl]-, 1,1-dimethylethyl ester
There total 6 articles about Carbamic acid,
[(2R,3S)-1-[bis(trimethylsilyl)methyl]-2-(2-methylpropyl)-4-oxo-3-(phenyl
methyl)-3-azetidinyl]-, 1,1-dimethylethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tributylphosphine;
In
tert-butyl alcohol;
at 70 ℃;
for 24h;
DOI:10.1021/ja038180a
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: LDA / tetrahydrofuran; hexane / 1 h / -78 °C
1.2: 1.295 g / tetrahydrofuran; hexane / -78 - 20 °C
2.1: acidic Amberlyst-15 resin; water / diethyl ether / 1 h / 20 °C
3.1: 1.34 g / tri(-n-butylphosphine) / 2-methyl-propan-2-ol / 24 h / 70 °C
With
tributylphosphine; acidic Amberlyst-15 resin; water; lithium diisopropyl amide;
In
tetrahydrofuran; diethyl ether; hexane; tert-butyl alcohol;
DOI:10.1021/ja038180a
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: Li / liquid ammonia; 2-methyl-propan-2-ol; CH2Cl2 / 0.08 h / -78 °C
2.1: molecular sieves 4 Angstroem / CH2Cl2 / 1 h / 20 °C
3.1: LDA / tetrahydrofuran; hexane / 1 h / -78 °C
3.2: 1.295 g / tetrahydrofuran; hexane / -78 - 20 °C
4.1: acidic Amberlyst-15 resin; water / diethyl ether / 1 h / 20 °C
5.1: 1.34 g / tri(-n-butylphosphine) / 2-methyl-propan-2-ol / 24 h / 70 °C
With
tributylphosphine; 4 A molecular sieve; acidic Amberlyst-15 resin; water; lithium; lithium diisopropyl amide;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; ammonia; tert-butyl alcohol;
DOI:10.1021/ja038180a
