Alanine, N-[[(2R,3R)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-(2-methylpropyl)- 4-oxo-3-(phenylmethyl)-1-azetidinyl]acetyl]-2-methyl-, phenylmethyl ester

Base Information

Chemical Name:Alanine, N-[[(2R,3R)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-(2-methylpropyl)- 4-oxo-3-(phenylmethyl)-1-azetidinyl]acetyl]-2-methyl-, phenylmethyl ester
CAS No.:651750-02-6
Molecular Formula:C32H43N3O6
Molecular Weight:565.71
Hs Code.:

Alanine,
N-[[(2R,3R)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-(2-methylpropyl)-
4-oxo-3-(phenylmethyl)-1-azetidinyl]acetyl]-2-methyl-, phenylmethyl ester

Synonyms:

Suppliers and Price of Alanine, N-[[(2R,3R)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-(2-methylpropyl)- 4-oxo-3-(phenylmethyl)-1-azetidinyl]acetyl]-2-methyl-, phenylmethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Alanine, N-[[(2R,3R)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-(2-methylpropyl)- 4-oxo-3-(phenylmethyl)-1-azetidinyl]acetyl]-2-methyl-, phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Alanine, N-[[(2R,3R)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-(2-methylpropyl)- 4-oxo-3-(phenylmethyl)-1-azetidinyl]acetyl]-2-methyl-, phenylmethyl ester

There total 10 articles about Alanine, N-[[(2R,3R)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-(2-methylpropyl)- 4-oxo-3-(phenylmethyl)-1-azetidinyl]acetyl]-2-methyl-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 651750-02-6
(3R,4R)-1-(3-aza-4-benzyloxycarbonyl-4-methyl-2-oxopentyl)-3-benzyl-3-tert-butoxycarbonylamino-4-isobutylazetidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 5.24 g / CH₂Cl₂ / 22 h / 20 °C

2: aq. (NH₄)2[Ce(NO₃)6] / acetonitrile / 2 h / 0 °C

3: 4.07 g / aq. NaHCO₃; Na₂CO₃ / methanol / 2 h / 20 °C

4: Cs₂CO₃ / acetonitrile / 3 h / 50 °C

5: 1.69 g / H₂ / Pd/C / ethyl acetate / 4 h / 760 Torr

6: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole; triethylamine / CH₂Cl₂; dimethylformamide / 0 - 20 °C

With ammonium cerium(IV) nitrate; hydrogen; sodium hydrogencarbonate; sodium carbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja038180a

Reference yield:

: 100-39-0
benzyl bromide

: 651750-02-6
(3R,4R)-1-(3-aza-4-benzyloxycarbonyl-4-methyl-2-oxopentyl)-3-benzyl-3-tert-butoxycarbonylamino-4-isobutylazetidin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: LDA / tetrahydrofuran / 1 h / -78 °C

1.2: 83 percent / tetrahydrofuran / -78 - 20 °C

2.1: Li / liquid ammonia; 2-methyl-propan-2-ol; tetrahydrofuran / 0.08 h / -78 °C

3.1: 5.24 g / CH₂Cl₂ / 22 h / 20 °C

4.1: aq. (NH₄)2[Ce(NO₃)6] / acetonitrile / 2 h / 0 °C

5.1: 4.07 g / aq. NaHCO₃; Na₂CO₃ / methanol / 2 h / 20 °C

6.1: Cs₂CO₃ / acetonitrile / 3 h / 50 °C

7.1: 1.69 g / H₂ / Pd/C / ethyl acetate / 4 h / 760 Torr

8.1: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole; triethylamine / CH₂Cl₂; dimethylformamide / 0 - 20 °C

With ammonium cerium(IV) nitrate; hydrogen; lithium; sodium hydrogencarbonate; sodium carbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ammonia; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1021/ja038180a

Reference yield:

: 198022-08-1
(3S,4R)-1-[bis(trimethylsilyl)methyl]-4-isobutyl-3-[(4S)-4-phenyl-2-oxo-oxazolidin-3-yl]-azetidin-2-one

: 651750-02-6
(3R,4R)-1-(3-aza-4-benzyloxycarbonyl-4-methyl-2-oxopentyl)-3-benzyl-3-tert-butoxycarbonylamino-4-isobutylazetidin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: LDA / tetrahydrofuran / 1 h / -78 °C

1.2: 83 percent / tetrahydrofuran / -78 - 20 °C

2.1: Li / liquid ammonia; 2-methyl-propan-2-ol; tetrahydrofuran / 0.08 h / -78 °C

3.1: 5.24 g / CH₂Cl₂ / 22 h / 20 °C

4.1: aq. (NH₄)2[Ce(NO₃)6] / acetonitrile / 2 h / 0 °C

5.1: 4.07 g / aq. NaHCO₃; Na₂CO₃ / methanol / 2 h / 20 °C

6.1: Cs₂CO₃ / acetonitrile / 3 h / 50 °C

7.1: 1.69 g / H₂ / Pd/C / ethyl acetate / 4 h / 760 Torr

8.1: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole; triethylamine / CH₂Cl₂; dimethylformamide / 0 - 20 °C

With ammonium cerium(IV) nitrate; hydrogen; lithium; sodium hydrogencarbonate; sodium carbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ammonia; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1021/ja038180a