2-(3-Chlorophenyl)benzofuran

Base Information

• Chemical Name: 2-(3-Chlorophenyl)benzofuran
• CAS No.: 65246-45-9
• Molecular Formula: C14H9ClO
• Molecular Weight: 228.678
• DSSTox Substance ID: DTXSID30441442
• Nikkaji Number: J678.853J
• Wikidata: Q82258209
• Mol file: 65246-45-9.mol

Synonyms:2-(3-chlorophenyl)benzofuran;65246-45-9;2-(3-chlorophenyl)-1-benzofuran;Benzofuran, 2-(3-chlorophenyl)-;DTXSID30441442;AKOS025139954

Chemical Property of 2-(3-Chlorophenyl)benzofuran

Chemical Property:

• XLogP3: 4.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 228.0341926
• Heavy Atom Count: 16
• Complexity: 243

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=C(O2)C3=CC(=CC=C3)Cl

Technology Process of 2-(3-Chlorophenyl)benzofuran

There total 28 articles about 2-(3-Chlorophenyl)benzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Iodophenol (533-58-4) + m-chlorophenylacetylene (766-83-6) → 2-(3-chlorophenyl)benzo[b]furan (65246-45-9)

Guidance literature:

With dichloro{2-[(1H-pyrazol-1-yl-κN²)methyl]-6-(1H-pyrazol-1-yl-κN²)pyridine-κN}copper(II); caesium carbonate; In 1,4-dioxane; at 130 ℃; for 48h; Sealed tube; Inert atmosphere;

DOI:10.1002/adsc.201301010

Reference yield: 98.0%

2-((3-chlorophenyl)ethynyl)phenol → 2-(3-chlorophenyl)benzo[b]furan (65246-45-9)

Guidance literature:

With potassium carbonate; In water; at 110 ℃; for 2h; Microwave irradiation; Inert atmosphere; Green chemistry;

DOI:10.1016/j.tet.2014.04.005

Reference yield: 98.0%

C14H8ClF → 2-(3-chlorophenyl)benzo[b]furan (65246-45-9)

Guidance literature:

With copper(l) iodide; potassium iodide; potassium hydroxide; In water; dimethyl sulfoxide; at 80 ℃; Schlenk technique;

DOI:10.3762/bjoc.10.305

upstream raw materials:

2-Iodophenol

m-chlorophenylacetylene

2-(3-chlorobenzyloxy)benzaldehyde

3-Chlorostyrene

Refernces

• 1、 Ji, Guijie,Duan, Yanan,Zhang, Shaochun,Yang, Yong. "Synthesis of benzofurans from terminal alkynes and iodophenols catalyzed by recyclable palladium nanoparticles supported on N,O-dual doped hierarchical porous carbon under copper- and ligand-free conditions". . p. 101 - 108. Retrieved 2018/05/05.
• 2、 Zheng, Hong-Xing,Shan, Xiang-Huan,Qu, Jian-Ping,Kang, Yan-Biao. "Strategy for Overcoming Full Reversibility of Intermolecular Radical Addition to Aldehydes: Tandem C-H and C-O Bonds Cleaving Cyclization of (Phenoxymethyl)arenes with Carbonyls to Benzofurans". . p. 3310 - 3313. Retrieved 2018/06/11.