766-83-6

Basic information

• Product Name: 3-Chlorophenylacetylene
• Synonyms: 3-Chlorophenylacetylene 99%;3-Chloro-1-ethynylbenzene 97%;Benzene, 1-chloro-3-ethynyl-;1-CHLORO-3-ETHYNYL-BENZENE;3-CHLORO-1-ETHYNYLBENZENE;3'-CHLOROPHENYL ACETYLENE;3-CHLOROPHENYLACETYLENE;SALOR-INT L308676-1EA
• CAS NO: 766-83-6
• Molecular Formula: C₈H₅Cl
• Molecular Weight: 136.58
• EINECS: 1533716-785-6
• Product Categories: Miscellaneous;Alkynyl;Halogenated Hydrocarbons;Organic Building Blocks
• Mol File: 766-83-6.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 178-179 °C(lit.)
• Flash Point: 145 °F
• Appearance: Clear colorless to yellow/Liquid
• Density: 1.109 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.719mmHg at 25°C
• Refractive Index: n20/D 1.5640(lit.)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-Chlorophenylacetylene(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chlorophenylacetylene(766-83-6)
• EPA Substance Registry System: 3-Chlorophenylacetylene(766-83-6)

Safety Data

• Hazard Codes: Xi
• Statements: 38
• Safety Statements: 36
• RIDADR: NA 1993 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 766-83-6(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to light yellow liquid

InChI:InChI=1/C8H5Cl/c1-2-7-4-3-5-8(9)6-7/h1,3-6H

Upstream product

• 79756-80-2 1-Chloro-3-(1,1-dichloro-ethyl)-benzene 
• 625-99-0 3-iodochlorobenzene 
• 74-86-2 acetylene 
• 7073-93-0 m-chlorocumene 
• 107-19-7 propargyl alcohol 
• 108-90-7 chlorobenzene 
• 71-43-2 benzene 
• 67-66-3 chloroform 
• 108-37-2 1-bromo-3-chlorobenzene 
• 1066-54-2 trimethylsilylacetylene 
• 5182-44-5 2-(3-chlorophenyl)ethanol 
• 90965-06-3 dimethyl 1-(1-diazo-2-oxopropyl)phosphonate 
• 587-04-2 m-Chlorobenzaldehyde 
• 766-80-3 1-bromomethyl-3-chlorobenzene 

Downstream Products

• 65246-45-9 2-(3-chlorophenyl)benzo[b]furan 
• 105279-17-2 (2Z) 2-(1-(3-chlorophenyl)methylene)benzofuran-3(2H)-one 
• 21886-56-6 3-chlorophenacyl chloride 
• 84553-19-5 m-(2-Chlorethinyl)-chlorbenzol 
• 84553-31-1 1-Chloro-3-((Z)-1,2-dichloro-vinyl)-benzene 
• 84553-26-4 2-Chloro-1-(3-chloro-phenyl)-butane-1,3-dione 
• 84553-20-8 α,α-dichloro-m-chloroacetophenone 
• 99-02-5 3'-Chloroacetophenone 
• 87992-00-5 2-(3-chlorophenyl)-2-oxoethyl acetate 
• 657424-77-6 ethyl 5-(3-chlorophenyl)isoxazole-3-carboxylate 
• 80221-18-7 1,4-bis(3-chlorophenyl)buta-1,3-diyne 
• 866684-64-2 3-bromo-5-(3-chlorophenylethynyl)-pyridine 
• 866684-52-8 3-(3-chlorophenylethynyl)-pyridine hydrochloride 
• 1118638-86-0 C₁₆H₂₀ClN 

Relevant articles and documents

SO2F2-Mediated Oxidative Dehydrogenation and Dehydration of Alcohols to Alkynes

Direct synthesis of alkynes from inexpensive, abundant alcohols was achieved in high yields (greater than 40 examples, up to 95% yield) through a SO2F2-promoted dehydration and dehydrogenation process. This straightforward transformation of sp3-sp3 (C-C) bonds to sp-sp (C=C) bonds requires only inexpensive and readily available reagents (no transition metals) under mild conditions. The crude alkynes are sufficiently free of impurities to permit direct use in further transformations, as illustrated by regioselective Huisgen alkyne-azide cycloaddition reactions with PhN3 to give 1,4-substituted 1,2,3-traiazoles (16 examples, up to 92% yield) and Sonogashira couplings (10 examples, up to 77% yield).

Cleavage of the Carbon–Carbon Triple Bonds of Arylacetylenes for the Synthesis of Arylnitriles without a Metal Catalyst

Cleavage of the carbon–carbon triple bonds of alkynes was achieved, which led to the synthesis of arylnitriles under transition-metal-free conditions. A vast range of terminal alkyne substrates underwent this reaction to provide the corresponding nitriles in moderate to good yields with good functional group tolerance.

"quick and click" assembly of functionalised indole rings via metal-promoted cyclative tandem reactions

An efficient and convenient synthesis of a variety of decorated indoles using a three-component tandem metal-catalysed process is described. We propose here a new "synthetic kit" that allows for the "quick and click" assembly of indole rings using readily available, and inexpensive starting materials under environmentally friendly reaction conditions. This journal is