5,7-Dioxa-2-aza-6-phosphanonanoic acid, 6-(1,1-dimethylethoxy)-3,8,8-trimethyl-3-[4-(4-octylphenyl)-1H-imidazol- 2-yl]-, 1,1-dimethylethyl ester, 6-sulfide

Base Information

Chemical Name:5,7-Dioxa-2-aza-6-phosphanonanoic acid, 6-(1,1-dimethylethoxy)-3,8,8-trimethyl-3-[4-(4-octylphenyl)-1H-imidazol- 2-yl]-, 1,1-dimethylethyl ester, 6-sulfide
CAS No.:654067-55-7
Molecular Formula:C33H56N3O5PS
Molecular Weight:637.865
Hs Code.:

5,7-Dioxa-2-aza-6-phosphanonanoic acid,
6-(1,1-dimethylethoxy)-3,8,8-trimethyl-3-[4-(4-octylphenyl)-1H-imidazol-
2-yl]-, 1,1-dimethylethyl ester, 6-sulfide

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5,7-Dioxa-2-aza-6-phosphanonanoic acid, 6-(1,1-dimethylethoxy)-3,8,8-trimethyl-3-[4-(4-octylphenyl)-1H-imidazol- 2-yl]-, 1,1-dimethylethyl ester, 6-sulfide

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Technology Process of 5,7-Dioxa-2-aza-6-phosphanonanoic acid, 6-(1,1-dimethylethoxy)-3,8,8-trimethyl-3-[4-(4-octylphenyl)-1H-imidazol- 2-yl]-, 1,1-dimethylethyl ester, 6-sulfide

There total 7 articles about 5,7-Dioxa-2-aza-6-phosphanonanoic acid, 6-(1,1-dimethylethoxy)-3,8,8-trimethyl-3-[4-(4-octylphenyl)-1H-imidazol- 2-yl]-, 1,1-dimethylethyl ester, 6-sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 654067-53-5
{2-hydroxy-1-methyl-1-[5-(4-octyl-phenyl)-1H-imidazol-2-yl]-ethyl}-carbamic acid tert-butyl ester

: 137348-86-8
di-tert-butyl diisopropylphosphoramide

: 654067-55-7
{2-(di-tert-butoxy-thiophosphoryloxy)-1-methyl-1-[5-(4-octyl-phenyl)-1H-imidazol-2-yl]-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: {2-hydroxy-1-methyl-1-[5-(4-octyl-phenyl)-1H-imidazol-2-yl]-ethyl}-carbamic acid tert-butyl ester; With 1H-tetrazole; In tetrahydrofuran; dichloromethane; acetonitrile; for 0.5h;

di-tert-butyl diisopropylphosphoramide; In tetrahydrofuran; dichloromethane; acetonitrile; for 12h;

With octasulfur; In tetrahydrofuran; dichloromethane; acetonitrile; for 12h;

Reference yield:

: 654642-54-3
2-amino-2-[5-(4-octyl-phenyl)-1H-imidazol-2-yl]-propan-1-ol

: 654067-55-7
{2-(di-tert-butoxy-thiophosphoryloxy)-1-methyl-1-[5-(4-octyl-phenyl)-1H-imidazol-2-yl]-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 57 percent / aq. Na₂CO₃ / tetrahydrofuran / 12 h / 20 °C

2: tetrazole / CH₂Cl₂; tetrahydrofuran / 12 h / 20 °C

3: S₈ / 3 h / 20 °C

With 1H-tetrazole; sulfur; sodium carbonate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2005.05.097

Reference yield:

: 654067-52-4
2,2,4-trimethyl-4-[5-(4-octyl-phenyl)-1H-imidazol-2-yl]-oxazolidine-3-carboxylic acid tert-butyl ester

: 654067-55-7
{2-(di-tert-butoxy-thiophosphoryloxy)-1-methyl-1-[5-(4-octyl-phenyl)-1H-imidazol-2-yl]-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 60 percent / p-TsOH / methanol / 3 h / 70 °C

2: 57 percent / aq. Na₂CO₃ / tetrahydrofuran / 12 h / 20 °C

3: tetrazole / CH₂Cl₂; tetrahydrofuran / 12 h / 20 °C

4: S₈ / 3 h / 20 °C

With 1H-tetrazole; sulfur; sodium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2005.05.097