654067-52-4

Upstream product

• 2189-60-8 Octylbenzene 
• 185525-61-5 (RS)-2,2,4-trimethyl-oxazolidine-3,4-dicarboxylic acid 3-tert-butyl ester 
• 64068-76-4 α-bromomethyl p(n-octyl)phenyl cetone 
• 191110-61-9 methyl 2-((tert-butoxycarbonyl)amino)-3-hydroxy-2-methylpropanoate 
• 654067-51-3 2,2,4-trimethyl-oxazolidine-3,4-dicarboxylic acid 3-tert-butyl ester 4-methyl ester 

Downstream Products

• 654642-54-3 2-amino-2-[5-(4-octyl-phenyl)-1H-imidazol-2-yl]-propan-1-ol 
• 654067-55-7 {2-(di-tert-butoxy-thiophosphoryloxy)-1-methyl-1-[5-(4-octyl-phenyl)-1H-imidazol-2-yl]-ethyl}-carbamic acid tert-butyl ester 
• 654067-54-6 {2-(di-tert-butoxy-phosphoryloxy)-1-methyl-1-[5-(4-octyl-phenyl)-1H-imidazol-2-yl]-ethyl}-carbamic acid tert-butyl ester 
• 654067-53-5 {2-hydroxy-1-methyl-1-[5-(4-octyl-phenyl)-1H-imidazol-2-yl]-ethyl}-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1- phosphate and FTY720: Discovery of potent S1P1 receptor agonists

The novel immunosuppressant FTY720 has been demonstrated to elicit immunomodulating effects via interaction with the G-protein coupled receptor S1P1. FTY720 induced agonism at the S1P3 receptor, however, has been shown to result in m

ORALLY AVAILABLE SPHINGOSINE 1-PHOSPHATE RECEPTOR AGONISTS AND ANTAGONISTS

The present invention relates to S1P analogs that have activity as S1Preceptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds have the general structure (I) wherein R11 is C5-C18 alkyl or C5-C18 alkenyl; Q is selected from the group consisting of C3-C6 optionally substituted cycloalkyl, C3-C6 optionally substituted heterocyclic, C3-C6 optionally substituted aryl C3-C6 optionally substituted heteroaryl and; R2 is selected from the group consisting of H, C1-C4 alkyl, (C1-C4 alkyl)OH and (C1-C4 alkyl)NH2; R23 is H or C1-C4 alkyl, and R15 is a phosphonate ester or a phosphate ester or a pharmaceutically acceptable salt or tautomer thereof.