Butanoic acid, 4-[2,6-bis[[4-[[3-iodo-5-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]ethynyl]-2, 5-dipropoxyphenyl]ethynyl]-4-methylphenoxy]-, methyl ester

Base Information

Chemical Name:Butanoic acid, 4-[2,6-bis[[4-[[3-iodo-5-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]ethynyl]-2, 5-dipropoxyphenyl]ethynyl]-4-methylphenoxy]-, methyl ester
CAS No.:654074-77-8
Molecular Formula:C66H70I2O11
Molecular Weight:1293.08
Hs Code.:

Butanoic acid,
4-[2,6-bis[[4-[[3-iodo-5-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]ethynyl]-2,
5-dipropoxyphenyl]ethynyl]-4-methylphenoxy]-, methyl ester

Synonyms:

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Chemical Property of Butanoic acid, 4-[2,6-bis[[4-[[3-iodo-5-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]ethynyl]-2, 5-dipropoxyphenyl]ethynyl]-4-methylphenoxy]-, methyl ester

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Technology Process of Butanoic acid, 4-[2,6-bis[[4-[[3-iodo-5-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]ethynyl]-2, 5-dipropoxyphenyl]ethynyl]-4-methylphenoxy]-, methyl ester

There total 4 articles about Butanoic acid, 4-[2,6-bis[[4-[[3-iodo-5-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]ethynyl]-2, 5-dipropoxyphenyl]ethynyl]-4-methylphenoxy]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 292632-58-7
3,5-diiodo-(tetrahydro-2H-pyran-2-yloxy)benzene

: 654074-76-7
methyl-4-{2,6-bis[2-(2,5-dipropyloxy-4-ethynylphenyl)ethynyl]-4-methyl}phenoxybutyrate

: 654074-77-8
methyl-4-{2,6-bis[2-(2,5-dipropyloxy-4-{2-[5-iodo-3-(tetrahydro-2H-pyran-2-yloxy)phenyl]ethynyl}phenyl)ethynyl]-4-methyl}phenoxybutyrate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In triethylamine; at 60 ℃; for 18h;
DOI:10.1021/ja038484x

Reference yield:

: 2432-18-0
2,6-diiodo-4-methylphenol

: 654074-77-8
methyl-4-{2,6-bis[2-(2,5-dipropyloxy-4-{2-[5-iodo-3-(tetrahydro-2H-pyran-2-yloxy)phenyl]ethynyl}phenyl)ethynyl]-4-methyl}phenoxybutyrate

Guidance literature:: Multi-step reaction with 4 steps

1.1: K₂CO₃; KI / dimethylformamide / 48 h / 60 °C

1.2: 73 percent / aq. acetic acid / CH₂Cl₂

2.1: 87 percent / triethylamine; tetrahydrofuran / 25 h / 20 - 50 °C

3.1: 74 percent / aq. Bu₄NF / tetrahydrofuran / 2 h / 20 °C

4.1: 81 percent / Pd(PPh₃)2Cl₂; CuI / triethylamine / 18 h / 60 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; potassium carbonate; potassium iodide; In tetrahydrofuran; triethylamine; N,N-dimethyl-formamide; 2.1: Hagihara-Sonogashira coupling;
DOI:10.1021/ja038484x

Reference yield:

: 654074-74-5
methyl 4-(2,6-diiodo-4-methyl)phenoxybutyrate

: 654074-77-8
methyl-4-{2,6-bis[2-(2,5-dipropyloxy-4-{2-[5-iodo-3-(tetrahydro-2H-pyran-2-yloxy)phenyl]ethynyl}phenyl)ethynyl]-4-methyl}phenoxybutyrate

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / triethylamine; tetrahydrofuran / 25 h / 20 - 50 °C

2: 74 percent / aq. Bu₄NF / tetrahydrofuran / 2 h / 20 °C

3: 81 percent / Pd(PPh₃)2Cl₂; CuI / triethylamine / 18 h / 60 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; In tetrahydrofuran; triethylamine; 1: Hagihara-Sonogashira coupling;
DOI:10.1021/ja038484x