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Phenol, 2,6-diiodo-4-methyl-, also known as 4-methyl-2,6-diiodophenol or 2,6-diiodo-4-methylphenol, is an organic compound with the chemical formula C7H6I2O. It is a derivative of phenol, where two iodine atoms are attached to the 2nd and 6th carbon atoms, and a methyl group is present at the 4th carbon atom. Phenol, 2,6-diiodo-4-methyl- is a white crystalline solid with a melting point of 142-144°C. It is soluble in organic solvents such as ethanol, acetone, and chloroform, but insoluble in water. Phenol, 2,6-diiodo-4-methyl-, has various applications in the chemical industry, including the synthesis of pharmaceuticals, agrochemicals, and dyes. Due to its reactivity and potential toxicity, it is important to handle Phenol, 2,6-diiodo-4-methyl- with care and follow proper safety procedures.

2432-18-0

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2432-18-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 2432-18-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,4,3 and 2 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 2432-18:
(6*2)+(5*4)+(4*3)+(3*2)+(2*1)+(1*8)=60
60 % 10 = 0
So 2432-18-0 is a valid CAS Registry Number.

2432-18-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,6-diiodo-4-methylphenol

1.2 Other means of identification

Product number -
Other names 2,6-diiodo-4-methyl-phenol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2432-18-0 SDS

2432-18-0Relevant articles and documents

Tolane-based bent bolaamphiphiles forming liquid crystalline hexagonal honeycombs with trigonal symmetry

Gao, Hongfei,Cheng, Huifang,Liu, Qijing,Xiao, Yulong,Prehm, Marko,Cheng, Xiaohong,Tschierske, Carsten

, p. 2060 - 2066 (2015)

Bolaamphiphiles consisting of a bent 1,3-bis(phenylethynyl)benzene core with two terminal glycerol units, a lateral n-alkyl chain in the bay-position and a methyl group at the apex of the central 1,3-substituted benzene ring have been synthesized via Sono

Iodine(III)-Mediated, Controlled Di- or Monoiodination of Phenols

Satkar, Yuvraj,Yera-Ledesma, Luisa F.,Mali, Narendra,Patil, Dipak,Segura-Quezada, Luis A.,Ramírez-Morales, Perla I.,Solorio-Alvarado, César R.,Navarro-Santos, Pedro

, p. 4149 - 4164 (2019/04/30)

An oxidative procedure for the electrophilic iodination of phenols was developed by using iodosylbenzene as a nontoxic iodine(III)-based oxidant and ammonium iodide as a cheap iodine atom source. A totally controlled monoiodination was achieved by buffering the reaction medium with K3PO4. This protocol proceeds with short reaction times, at mild temperatures, in an open flask, and generally with high yields. Gram-scale reactions, as well as the scope of this protocol, were explored with electron-rich and electron-poor phenols as well as heterocycles. Quantum chemistry calculations revealed PhII(OH)·NH3 to be the most plausible iodinating active species as a reactive "I+" synthon. In light of the relevance of the iodoarene moiety, we present herein a practical, efficient, and simple procedure with a broad functional group scope that allows access to the iodoarene core unit.

Synthesis of Silylbiaryl Triflates by Chemoselective Suzuki Reaction

Moreira, Bárbara V.,Muraca, Ana Carolina A.,Raminelli, Cristiano

supporting information, p. 1093 - 1102 (2017/02/24)

A modular approach for the synthesis of functionalized silylbiaryl triflates has been developed. Iodinated silylaryl triflates were prepared via a gram-scale diiodination reaction, followed by a one-flask transformation, in 42-52% overall yield. The iodin

Enhancing the synthetic utility of 3-haloaryne intermediates by their efficient Generation from readily synthesizable ortho-iodoaryl triflate-type precursors

Yoshida, Suguru,Nagai, Akira,Uchida, Keisuke,Hosoya, Takamitsu

supporting information, p. 733 - 736 (2017/09/01)

Generation of 3-haloarynes from o-iodoaryl triflate-type precursors is reported. The method enables the generation of 3-fluorobenzyne with significantly high electrophilicity at -78 °C, allowing the formation of a three-component-coupled product between 3

Molybdenum and Tungsten Alkylidene Complexes That Contain a 2-Pyridyl-Substituted Phenoxide Ligand

Sues, Peter E.,John, Jeremy M.,Bukhryakov, Konstantin V.,Schrock, Richard R.,Müller, Peter

supporting information, p. 3587 - 3593 (2016/11/06)

In the interest of preparing molybdenum and tungsten alkylidene complexes for olefin metathesis that are longer-lived at high temperatures (~150 °C or above), we synthesized complexes that contain a phenoxide ligand with a 2-pyridyl in one ortho position and a mesityl (Mes) or 2,4,6-i-Pr3C6H2 (Trip) in the other ortho position ([MesON]- or [TripON]-, respectively). The alkylidene (neophylidene) complexes that were prepared include W(O)(CHCMe2Ph)(Me2Pyr)(RON) (R = Mes or Trip), Mo(NC6F5)(CHCMe2Ph)(RON)Cl, Mo(N-2,6-Me2C6H3)(CHCMe2Ph)(RON)Cl, Mo(N-t-Bu)(CHCMe2Ph)(RON)Cl, and M(N-2,6-i-Pr2C6H3)(CHCMe2Ph)(TripON)(OTf) (M = Mo or W). The reaction between Mo(NAr)(CHCMe2Ph)(TripON)(OTf) and ethylene yielded an ethylene complex, Mo(NAr)(C2H4)(TripON)(OTf)(ether). All neophylidene complexes were essentially unreactive toward terminal olefins at 22 °C and showed modest homocoupling activity (at 80 or 100 °C) and alkane metathesis activity (at 150 and 200 °C). W(O)(CHCMe2Ph)(Me2Pyr)(MesON) also stereoselectively polymerized several substituted norbornadienes at 100 °C.

Ultrasound-promoted rapid and efficient iodination of aromatic and heteroaromatic compounds in the presence of iodine and hydrogen peroxide in water

Ferreira, Irlon M.,Casagrande, Gleison A.,Pizzuti, Lucas,Raminelli, Cristiano

supporting information, p. 2094 - 2102 (2014/07/07)

A rapid and efficient ultrasound-promoted protocol for iodination of aromatic and heteroaromatic compounds, using molecular iodine in the presence of aqueous hydrogen peroxide in water without any cosolvent, has produced versatile iodinated organic molecules with potential application in organic synthesis and medicine in short reaction times and good to excellent yields. Copyright

One-pot synthesis of 2,2′-bisbenzofurans using cuprous chloride as a catalyst

Pan, Wen-Bin,Chen, Chin-Chau,Wei, Li-Lan,Wei, Li-Mei,Wu, Ming-Jung

, p. 2655 - 2657 (2013/06/05)

A variety of novel 5,5′-disubstituted-2,2′-bisbenzofuran derivatives were synthesized by treatment of 4-substituted-2-(2- trimethylsilylethynyl)phenyl tert-butyldimethylsilyl ether analogues with CuCl as a catalyst in 62-82% isolated yields. This novel st

Small-molecular, non-peptide, non-ATP-competitive polo-like kinase 1 (Plk1) inhibitors with a terphenyl skeleton

Mita, Yusuke,Noguchi-Yachide, Tomomi,Ishikawa, Minoru,Hashimoto, Yuichi

, p. 608 - 617 (2013/02/25)

Polo-like kinase (Plk) 1 is a serine-threonine protein kinase that plays a role in cell division, and its overexpression is highly correlated with aggressiveness and prognosis of many cancers. We have designed, synthesized and evaluated a series of terphe

Regiocomplementary cycloaddition reactions of boryl- and silylbenzynes with 1,3-dipoles: Selective synthesis of benzo-fused azole derivatives

Ikawa, Takashi,Takagi, Akira,Goto, Masahiko,Aoyama, Yuya,Ishikawa, Yoshinobu,Itoh, Yuji,Fujii, Satoshi,Tokiwa, Hiroaki,Akai, Shuji

, p. 2965 - 2983 (2013/06/26)

Benzo-fused nitrogen-containing heterocycles are abundant in biologically active compounds. One of the most important methods for preparing such heterocycles is the (3 + 2) cycloaddition reaction of benzynes with 1,3-dipolar compounds. However, the reacti

Gas-Chromatographic identifi cation of products formed in iodination of methyl phenols by retention indices

Gruzdev,Kuzivanov,Zenkevich,Kondratenok

, p. 1355 - 1365 (2013/01/15)

Iodination reaction followed by conversion of iodine-substituted methylphenols to the corresponding trifl uoroacetates was suggested for improving the sensitivity of the gas-chromatographic determination of phenol and its methyl-substituted derivatives (al isomers of mono- and diethylphenols, 2,3,5-, 2,3,6-, and 3,4,5-trimethylphenols) in aqueous media. Acylation products of iodo methylphenols (104 compounds) were identifi ed by linear-logarithmic retention indices on a standard nonpolar polydimethylsiloxane stationary phase, and the pattern of their variation with the number and nature of substituents were characterized. A procedure for identifi cation of methyl-substituted phenols in water in their gas-chromatographic determination with an electron-capture detector was developed. Pleiades Publishing, Ltd., 2012.

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