2',4'-DIFLUORO-3-(4-FLUOROPHENYL)PROPIOPHENONE

Base Information

• Chemical Name: 2',4'-DIFLUORO-3-(4-FLUOROPHENYL)PROPIOPHENONE
• CAS No.: 654673-34-4
• Molecular Formula: C₁₅H₁₁F₃O
• Molecular Weight: 264.247
• Hs Code.: 2914700090
• Mol file: 654673-34-4.mol

Synonyms:2',4'-DIFLUORO-3-(4-FLUOROPHENYL)PROPIOPHENONE;(4-fluorophenethyl)-(2,4-difluorophenyl)-ketone;

Chemical Property of 2',4'-DIFLUORO-3-(4-FLUOROPHENYL)PROPIOPHENONE

Chemical Property:

• Vapor Pressure: 1.73E-05mmHg at 25°C
• Boiling Point: 364oC at 760 mmHg
• Flash Point: 182.6oC
• PSA: 17.07000
• Density: 1.253g/cm3
• LogP: 3.91940

Purity/Quality:

97% ^*data from raw suppliers

2',4'-Difluoro-3-(4-fluorophenyl)propiophenone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2',4'-DIFLUORO-3-(4-FLUOROPHENYL)PROPIOPHENONE

There total 4 articles about 2',4'-DIFLUORO-3-(4-FLUOROPHENYL)PROPIOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-1-(2,4-difluorophenyl)-3-(4-fluorophenyl)prop-2-en-1-one → (4-fluorophenethyl)-(2,4-difluorophenyl)-ketone (654673-34-4)

Guidance literature:

With formic acid; tributyl-amine; palladium on activated charcoal; at 100 ℃; for 10h;

Reference yield:

2',4'-difluoroacetophenone (364-83-0) → (4-fluorophenethyl)-(2,4-difluorophenyl)-ketone (654673-34-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol / 20 °C

2: formic acid; tributylamine / Pd/C / 10 h / 100 °C

With sodium hydroxide; formic acid; tributyl-amine; palladium on activated charcoal; In ethanol;

Reference yield:

4-fluorobenzaldehyde (459-57-4) → (4-fluorophenethyl)-(2,4-difluorophenyl)-ketone (654673-34-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol / 20 °C

2: formic acid; tributylamine / Pd/C / 10 h / 100 °C

With sodium hydroxide; formic acid; tributyl-amine; palladium on activated charcoal; In ethanol;

upstream raw materials:

2',4'-difluoroacetophenone

4-fluorobenzaldehyde

Refernces

• 1、 Karki, Rajeshri G.,Gokhale, Vijay M.,Kharkar, Prashant S.,Kulkarni, Vithal M.. "Azole compounds designed by molecular modelling show antifungal activity as predicted". . p. 372 - 381. Retrieved 2007/10/03.