Technology Process of 1H-Imidazole-1-carbothioic acid,
O-[(1S,2R,3S,4S,6S)-4-[(phenylmethoxy)methyl]-3-(2-propenyl)-7-oxabi
cyclo[4.1.0]hept-2-yl] ester
There total 8 articles about 1H-Imidazole-1-carbothioic acid,
O-[(1S,2R,3S,4S,6S)-4-[(phenylmethoxy)methyl]-3-(2-propenyl)-7-oxabi
cyclo[4.1.0]hept-2-yl] ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap;
In
dichloromethane;
for 1.5h;
Heating;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 100 percent / toluene / 3 h / 180 °C
2.1: 94 percent / I2; H2O / 1,2-dimethoxy-ethane / 26 h / 20 °C
3.1: 96 percent / DBU / benzene / 3 h / Heating
4.1: 2.16 g / DIBALH / diethyl ether; hexane / 0.5 h / -78 °C
5.1: NaN(TMS)2 / tetrahydrofuran / 0.25 h
5.2: tetrahydrofuran / 0.33 h / -78 °C
5.3: 100 percent / tetrahydrofuran / 2 h / Heating
6.1: Ph3P; DEAD; p-nitrobenzoic acid / tetrahydrofuran / 0 - 20 °C
6.2: 42 percent / LiOH*H2O / tetrahydrofuran; H2O / 6.5 h / 20 °C
7.1: 95 percent / m-CPBA / CH2Cl2 / 19 h / 20 °C
8.1: 100 percent / DMAP / CH2Cl2 / 1.5 h / Heating
With
dmap; water; iodine; sodium hexamethyldisilazane; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; diethylazodicarboxylate; 4-nitro-benzoic acid;
In
tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; hexane; dichloromethane; toluene; benzene;
5.2: Wittig reaction / 5.3: Wittig reaction / 6.1: Mitsunobu reaction;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: NaN(TMS)2 / tetrahydrofuran / 0.25 h
1.2: tetrahydrofuran / 0.33 h / -78 °C
1.3: 100 percent / tetrahydrofuran / 2 h / Heating
2.1: Ph3P; DEAD; p-nitrobenzoic acid / tetrahydrofuran / 0 - 20 °C
2.2: 42 percent / LiOH*H2O / tetrahydrofuran; H2O / 6.5 h / 20 °C
3.1: 95 percent / m-CPBA / CH2Cl2 / 19 h / 20 °C
4.1: 100 percent / DMAP / CH2Cl2 / 1.5 h / Heating
With
dmap; sodium hexamethyldisilazane; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; diethylazodicarboxylate; 4-nitro-benzoic acid;
In
tetrahydrofuran; dichloromethane;
1.2: Wittig reaction / 1.3: Wittig reaction / 2.1: Mitsunobu reaction;
