3',4',7,8-Tetramethoxyflavone

Base Information

• Chemical Name: 3',4',7,8-Tetramethoxyflavone
• CAS No.: 65548-55-2
• Molecular Formula: C19H18O6
• Molecular Weight: 342.348
• Hs Code.: 2914509090
• DSSTox Substance ID: DTXSID70398663
• Nikkaji Number: J687.364B
• Wikidata: Q82200772
• ChEMBL ID: CHEMBL321555

Synonyms:65548-55-2;3',4',7,8-Tetramethoxyflavone;2-(3,4-dimethoxyphenyl)-7,8-dimethoxy-4H-chromen-4-one;2-(3,4-dimethoxyphenyl)-7,8-dimethoxychromen-4-one;CHEMBL321555;4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-7,8-dimethoxy-;SCHEMBL988001;2-(3,4-Dimethoxy-phenyl)-7,8-dimethoxy-chromen-4-one;7,8,3',4'-tetramethoxyflavone;DTXSID70398663;ZRLWYUNKZNRQLO-UHFFFAOYSA-N;BDBM50032155;MFCD00143001;AKOS024287230;AS-59240;3',4',7,8-tetramethoxyflavone, AldrichCPR;FT-0614179;A1-03162;7,8-dimethoxy-2-(3,4-dimethoxyphenyl)-4h-chromen-4-one

Chemical Property of 3',4',7,8-Tetramethoxyflavone

Chemical Property:

• Melting Point: 206-208oC
• Boiling Point: 512.1oC at 760 mmHg
• Flash Point: 226.3oC
• PSA: 67.13000
• Density: 1.243g/cm3
• LogP: 3.49440
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 5
• Exact Mass: 342.11033829
• Heavy Atom Count: 25
• Complexity: 504

Purity/Quality:

98%Min ^*data from raw suppliers

3'',4'',7,8-Tetramethoxyflavone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): 330821
• Hazard Codes: T
• Statements: 25
• Safety Statements: 22-24/25-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C=C3)OC)OC)OC

Technology Process of 3',4',7,8-Tetramethoxyflavone

There total 15 articles about 3',4',7,8-Tetramethoxyflavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2'-hydroxy-3',4',3,4-tetramethoxychalcone (94285-19-5) → 3',4',7,8-(OMe)4-flavon (65548-55-2)

Guidance literature:

With hydrogenchloride; tetra-(n-butyl)ammonium iodide; In ethanol; for 96h; Heating;

Reference yield:

2,3-dimethoxyphenol (5150-42-5) → 3',4',7,8-(OMe)4-flavon (65548-55-2)

Guidance literature:

Multi-step reaction with 3 steps

1: N,N'-dicyclohexylcarbodiimide, 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 0.25 h / Ambient temperature

2: CH₂Cl₂ / 0.17 h / Irradiation

3: 61 percent / SeO₂ / dimethylsulfoxide / 1 h / 120 °C

With dmap; selenium(IV) oxide; dicyclohexyl-carbodiimide; In dichloromethane; dimethyl sulfoxide;

DOI:10.1021/jm00014a032

Reference yield:

1-(3,4-dimethoxyphenyl)-3-(2-hydroxy-3,4-dimethoxyphenyl)-1,3-propanedione (460744-76-7) → 3',4',7,8-(OMe)4-flavon (65548-55-2)

Guidance literature:

1-(3,4-dimethoxyphenyl)-3-(2-hydroxy-3,4-dimethoxyphenyl)-1,3-propanedione; With sulfuric acid; acetic acid; at 90 - 110 ℃; for 1h;

In chloroform; at 0 - 20 ℃; for 0.5h;

DOI:10.1039/c6ra11041j

upstream raw materials:

2'-hydroxy-3',4',3,4-tetramethoxychalcone

ethanol

(2RS:3SR)-2,3-dibromo-3-(3,4-dimethoxy-phenyl)-1-(3,4-dimethoxy-2-acetoxy-phenyl)-propanone-⁽¹⁾

3,4-dimethoxycinnamic acid

Downstream raw materials:

3',4',7,8-tetrahydroxyflavone

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