1-(2H,5H-[1,3]Dioxolo[4,5-f]indol-7-yl)-2-(piperidin-1-yl)ethane-1,2-dione

Base Information

Chemical Name:1-(2H,5H-[1,3]Dioxolo[4,5-f]indol-7-yl)-2-(piperidin-1-yl)ethane-1,2-dione
CAS No.:6560-18-5
Molecular Formula:C16H16N2O4
Molecular Weight:300.314
Hs Code.:
DSSTox Substance ID:DTXSID80521263
Wikidata:Q82385645

Synonyms:6560-18-5;DTXSID80521263;1-(2H,5H-[1,3]Dioxolo[4,5-f]indol-7-yl)-2-(piperidin-1-yl)ethane-1,2-dione

Suppliers and Price of 1-(2H,5H-[1,3]Dioxolo[4,5-f]indol-7-yl)-2-(piperidin-1-yl)ethane-1,2-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 1-(2H,5H-[1,3]Dioxolo[4,5-f]indol-7-yl)-2-(piperidin-1-yl)ethane-1,2-dione

Chemical Property:

XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:300.11100700
Heavy Atom Count:22
Complexity:463

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CCN(CC1)C(=O)C(=O)C2=CNC3=CC4=C(C=C32)OCO4

Technology Process of 1-(2H,5H-[1,3]Dioxolo[4,5-f]indol-7-yl)-2-(piperidin-1-yl)ethane-1,2-dione

There total 3 articles about 1-(2H,5H-[1,3]Dioxolo[4,5-f]indol-7-yl)-2-(piperidin-1-yl)ethane-1,2-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 110-89-4
piperidine

: 88048-26-4
5,6-methylenedioxyindole-3-glyoxyl chloride

: 6560-18-5
1-(5H-[1,3]Dioxolo[4,5-f]indol-7-yl)-2-piperidin-1-yl-ethane-1,2-dione

Guidance literature:: In tetrahydrofuran; diethyl ether; at 0 ℃; pH > 9;
DOI:10.1002/jhet.5570200438

Reference yield:

: 15794-43-1
6,β-dinitro-3,4-methylenedioxystyrene

: 6560-18-5
1-(5H-[1,3]Dioxolo[4,5-f]indol-7-yl)-2-piperidin-1-yl-ethane-1,2-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 64 percent / H₂ / 10percent Pd/C / ethanol; acetic acid; ethyl acetate / 0.75 h / 2068.6 - 2844.3 Torr

2: diethyl ether / 0.5 h / 0 °C

3: 46 percent / tetrahydrofuran; diethyl ether / 0 °C / pH > 9

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; acetic acid; ethyl acetate;
DOI:10.1002/jhet.5570200438

Reference yield:

: 267-48-1
5,6-methylenedioxyindole

: 6560-18-5
1-(5H-[1,3]Dioxolo[4,5-f]indol-7-yl)-2-piperidin-1-yl-ethane-1,2-dione

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether / 0.5 h / 0 °C

2: 46 percent / tetrahydrofuran; diethyl ether / 0 °C / pH > 9

In tetrahydrofuran; diethyl ether;
DOI:10.1002/jhet.5570200438